KCNE3 and KIF5A

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		KCNE3	KIF5A
Description		potassium voltage-gated channel subfamily E regulatory subunit 3	kinesin family member 5A
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Dendrite Vesicle Neuronal Cell Body Membrane Perikaryon Membrane Raft Basolateral Part Of Cell	Cytosol Kinesin Complex Microtubule Membrane Dendrite Cytoplasm Ciliary Rootlet Perikaryon Synapse Perinuclear Region Of Cytoplasm Axon Cytoplasm
	Molecular Function	Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Kinesin Binding
	Biological Process	Sodium Ion Transport Cellular Chloride Ion Homeostasis Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential	Microtubule-based Movement Chemical Synaptic Transmission Axon Guidance Vesicle-mediated Transport Cytoskeleton-dependent Intracellular Transport Synaptic Vesicle Transport Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Retrograde Neuronal Dense Core Vesicle Transport
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase	MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs		Enflurane Promethazine Miconazole
Diseases
GWAS		Corneal astigmatism ( 22144915) Neuritic plaque ( 31497858)	Amyotrophic lateral sclerosis ( 29566793) Rheumatoid arthritis ( 24449572 18794853) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		10 interacting genes: C11orf68 EEF1A1 GAPDH GOLM1 KIF5A LRIF1 POLA2 QARS1 RASSF1 SLC44A1	21 interacting genes: CREBBP DTNB ITSN1 KCNE3 KIF5B KIF5C KLC3 MAP4K4 MAPK10 NCOA2 NDEL1 PIN1 RAPGEF2 SMN1 TK1 TP53BP2 TRIM55 TRIM63 TSC1 TSG101 YAP1
Entrez ID		10008	3798
HPRD ID		07256	09108
Ensembl ID		ENSG00000175538	ENSG00000155980
Uniprot IDs		Q6IAE6 Q9Y6H6	Q12840
PDB IDs		2NDJ 6V00 6V01	4UXT 4UXY 4UY0
Enriched GO Terms of Interacting Partners?
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