RBX1 and GLMN

Data Source:
BioGRID (affinity chromatography technology, two hybrid, pull down, pull down)

		RBX1	GLMN
Description		ring-box 1	glomulin, FKBP associated protein
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex	Cytoplasm Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein-containing Complex Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Cullin Family Protein Binding	Signaling Receptor Binding Hepatocyte Growth Factor Receptor Binding Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Inhibitor Activity
	Biological Process	MAPK Cascade Protein Polyubiquitination Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination SCF Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Wnt Signaling Pathway Protein Ubiquitination Protein Phosphopantetheinylation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleotide-excision Repair, DNA Incision DNA Damage Response, Detection Of DNA Damage Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Protein Neddylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Global Genome Nucleotide-excision Repair Protein K48-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Autoubiquitination	Vasculogenesis Positive Regulation Of Cytokine Production Neural Tube Closure Cell Surface Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-2 Production Regulation Of Gene Expression, Epigenetic Negative Regulation Of T Cell Proliferation Positive Regulation Of Phosphorylation Muscle Cell Differentiation
Pathways		Recognition of DNA damage by PCNA-containing replication complex Prolactin receptor signaling Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Vif-mediated degradation of APOBEC3G Degradation of beta-catenin by the destruction complex NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Degradation of DVL Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Orc1 removal from chromatin FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Venous malformations, including: Sporadic venous malformation; Cutaneomucosal venous malformation; Glomuvenous malformation
GWAS		Alcohol use disorder (consumption score) ( 30940813) Allergic rhinitis ( 25085501) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Crohn's disease ( 22936669) LDL cholesterol levels ( 32203549) Neuroticism ( 29255261) Refractive error ( 32231278)	Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252)
Interacting Genes		65 interacting genes: APP ARIH1 CAND1 CAND2 CCND1 CDC34 CDKN1B COPS4 COPS6 CRBN CSNK1E CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 DCAF1 DTL ERBIN ERCC8 FBH1 FBXW8 FRZB GHR GLMN GPS1 HAX1 KCTD17 KPNB1 KRTAP12-2 MAGEC2 MAP3K20 MAP3K7 MAPK8IP2 MKNK2 MYB OS9 PBX4 PML PRAME RHOBTB3 RNF126 RPS6KB1 SERTAD1 SKP1 SMAD3 TAB1 TRIM27 TRIM74 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2M UBE2R2 VHL VRK2	16 interacting genes: BIRC2 BIRC3 EFS FBXW7 FKBP1A FKBP4 FKBP5 HSPB1 MET NSFL1C PEX5 PRDM16 RBX1 RNF7 SKP1 SNAI1
Entrez ID		9978	11146
HPRD ID		06794	03451
Ensembl ID		ENSG00000100387	ENSG00000174842
Uniprot IDs		P62877	B4DJ85 Q92990
PDB IDs		1LDJ 1LDK 1U6G 2HYE 2LGV 3DPL 3DQV 3RTR 4F52 4P5O 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N 6TTU	4F52
Enriched GO Terms of Interacting Partners?
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