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RBX1 and CUL4A
Data Source:
BioGRID
(affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD
(in vivo)
RBX1
CUL4A
Description
ring-box 1
cullin 4A
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
SCF Ubiquitin Ligase Complex
VCB Complex
Cullin-RING Ubiquitin Ligase Complex
Cul2-RING Ubiquitin Ligase Complex
Cul3-RING Ubiquitin Ligase Complex
Cul4A-RING E3 Ubiquitin Ligase Complex
Cul4B-RING E3 Ubiquitin Ligase Complex
Cul5-RING Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
Nucleoplasm
SCF Ubiquitin Ligase Complex
Cullin-RING Ubiquitin Ligase Complex
Cul4A-RING E3 Ubiquitin Ligase Complex
Cul4-RING E3 Ubiquitin Ligase Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
NEDD8 Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein-containing Complex Binding
Ubiquitin Protein Ligase Activity
NEDD8 Ligase Activity
Cullin Family Protein Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Biological Process
MAPK Cascade
Protein Polyubiquitination
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
SCF Complex Assembly
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
Protein Phosphopantetheinylation
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Nucleotide-excision Repair, DNA Incision
DNA Damage Response, Detection Of DNA Damage
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Protein Neddylation
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Global Genome Nucleotide-excision Repair
Protein K48-linked Ubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Autoubiquitination
G1/S Transition Of Mitotic Cell Cycle
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
In Utero Embryonic Development
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Cell Population Proliferation
Viral Process
Protein Ubiquitination
Hemopoiesis
Negative Regulation Of Granulocyte Differentiation
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Nucleotide-excision Repair, DNA Incision
Somatic Stem Cell Population Maintenance
Ribosome Biogenesis
DNA Damage Response, Detection Of DNA Damage
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Rhythmic Process
Regulation Of Protein Metabolic Process
Global Genome Nucleotide-excision Repair
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of DNA Damage Checkpoint
Regulation Of Nucleotide-excision Repair
Pathways
Recognition of DNA damage by PCNA-containing replication complex
Prolactin receptor signaling
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Vif-mediated degradation of APOBEC3G
Degradation of beta-catenin by the destruction complex
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Degradation of DVL
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Orc1 removal from chromatin
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Recognition of DNA damage by PCNA-containing replication complex
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Neddylation
Drugs
Diseases
GWAS
Alcohol use disorder (consumption score) (
30940813
)
Allergic rhinitis (
25085501
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Crohn's disease (
22936669
)
LDL cholesterol levels (
32203549
)
Neuroticism (
29255261
)
Refractive error (
32231278
)
Apolipoprotein A1 levels (
32203549
)
Atrial fibrillation (
30061737
)
Bipolar disorder (
31043756
)
Blood protein levels (
28240269
)
HDL cholesterol levels (
32203549
)
Immature fraction of reticulocytes (
32888494
)
Intracranial aneurysm (
30823506
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Platelet distribution width (
32888494
27863252
)
Red cell distribution width (
32888494
)
Interacting Genes
65 interacting genes:
APP
ARIH1
CAND1
CAND2
CCND1
CDC34
CDKN1B
COPS4
COPS6
CRBN
CSNK1E
CUL1
CUL2
CUL3
CUL4A
CUL4B
CUL5
CUL7
DCAF1
DTL
ERBIN
ERCC8
FBH1
FBXW8
FRZB
GHR
GLMN
GPS1
HAX1
KCTD17
KPNB1
KRTAP12-2
MAGEC2
MAP3K20
MAP3K7
MAPK8IP2
MKNK2
MYB
OS9
PBX4
PML
PRAME
RHOBTB3
RNF126
RPS6KB1
SERTAD1
SKP1
SMAD3
TAB1
TRIM27
TRIM74
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2L3
UBE2L6
UBE2M
UBE2R2
VHL
VRK2
24 interacting genes:
CAND1
CDKN1B
CENPA
CHEK1
COMMD1
COPS5
DCAF6
DCUN1D4
DDB1
DDB2
ERCC8
GPS1
H1-2
H3C1
HOXA9
KPNB1
RBX1
RNF7
SALL2
SENP8
SKP2
TUBG1
UBC
UBE2E3
Entrez ID
9978
8451
HPRD ID
06794
07218
Ensembl ID
ENSG00000100387
ENSG00000139842
Uniprot IDs
P62877
A0A0A0MR50
Q13619
PDB IDs
1LDJ
1LDK
1U6G
2HYE
2LGV
3DPL
3DQV
3RTR
4F52
4P5O
5N4W
6R6H
6R7F
6R7H
6R7I
6R7N
6TTU
2HYE
4A0K
Enriched GO Terms of Interacting Partners
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