CCP110 and PCNT

Data Source:
HPRD (in vivo)

		CCP110	PCNT
Description		centriolar coiled-coil protein 110	pericentrin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Centrosome Centriole Cytosol Cilium Protein-containing Complex	Centrosome Centriole Cytosol Microtubule Membrane Centriolar Satellite
	Molecular Function	Protein Binding	Protein Binding Calmodulin Binding Molecular Adaptor Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Ciliary Basal Body Organization Regulation Of Cytokinesis Positive Regulation Of Cilium Assembly Centrosome Duplication Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of Cilium Assembly Negative Regulation Of Centriole Elongation	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Spindle Organization Signal Transduction Regulation Of G2/M Transition Of Mitotic Cell Cycle Cilium Assembly Positive Regulation Of Intracellular Protein Transport Ciliary Basal Body-plasma Membrane Docking
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Ub-specific processing proteases AURKA Activation by TPX2	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs
Diseases			Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome
GWAS			Heel bone mineral density ( 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) Treatment resistant depression ( 30468137)
Interacting Genes		13 interacting genes: AKAP9 CALM1 CALM3 CDK1 CDK2 CEP97 CETN1 CETN2 DCAF1 PCNT PNMA1 TFIP11 USP33	11 interacting genes: AKAP9 CALM1 CALM2 CCP110 CEP55 DISC1 PCM1 TP53BP1 TUBG1 TUBGCP2 TUBGCP3
Entrez ID		9738	5116
HPRD ID		10848	05804
Ensembl ID		ENSG00000103540	ENSG00000160299
Uniprot IDs		O43303	O95613
PDB IDs
Enriched GO Terms of Interacting Partners?
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