DHX34 and POLA2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DHX34	POLA2
Description		DExH-box helicase 34	DNA polymerase alpha 2, accessory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Intracellular Anatomical Structure Membrane	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	RNA Binding RNA Helicase Activity ATP Binding	Molecular_function DNA Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs			Dacarbazine
Diseases
GWAS			Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)
Interacting Genes		3 interacting genes: GSK3B POLA2 RPS6KA6	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		9704	23649
HPRD ID		13144	10160
Ensembl ID		ENSG00000134815	ENSG00000014138
Uniprot IDs		Q14147	Q14181
PDB IDs			2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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