DZIP3 and TNFRSF18

Data Source:
BioGRID (affinity chromatography technology)

		DZIP3	TNFRSF18
Description		DAZ interacting zinc finger protein 3	TNF receptor superfamily member 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Phosphatase Binding Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Tumor Necrosis Factor-activated Receptor Activity Protein Binding
	Biological Process	Protein Polyubiquitination	Positive Regulation Of Leukocyte Migration Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Cell Adhesion
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	TNFs bind their physiological receptors RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs
Diseases
GWAS		Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252)	Inflammatory bowel disease ( 23128233)
Interacting Genes		52 interacting genes: AKTIP AP1M1 ARHGAP32 ATXN1 BAG4 BIRC2 BIRC3 CARM1 CEP63 DAZ1 FBXO17 GRIP1 GTF2H2C_2 HNRNPF HNRNPH1 HNRNPUL1 HOTAIR HOXC8 MIR20A MIR29C NCOR1 PCGF3 PITX1 RAD18 RBM4B RNF38 RUNX1 TNS2 TOLLIP TRIM21 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2N UBE2R2 UBE2U UBE2V1 UBE2V2 UBE2W UBE2Z UBR3 ZCCHC10 ZNF24 ZNF765	6 interacting genes: LNX1 TNFSF18 TRAF1 TRAF2 TRAF3 UBQLN2
Entrez ID		9666	8784
HPRD ID		10562	04879
Ensembl ID		ENSG00000198919	ENSG00000186891
Uniprot IDs		Q86Y13	A0A0R7FDM1 Q9Y5U5
PDB IDs
Enriched GO Terms of Interacting Partners?
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