CD59 and CD8A

Data Source:
BioGRID (pull down)

		CD59	CD8A
Description		CD59 molecule (CD59 blood group)	CD8a molecule
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Anchored Component Of External Side Of Plasma Membrane Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane T Cell Receptor Complex Plasma Membrane Raft
	Molecular Function	Complement Binding Protein Binding	Protein Binding Coreceptor Activity MHC Class I Protein Complex Binding MHC Class I Protein Binding
	Biological Process	Negative Regulation Of Activation Of Membrane Attack Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cell Surface Receptor Signaling Pathway Blood Coagulation Regulation Of Complement Activation Neutrophil Degranulation COPII Vesicle Coating Regulation Of Complement-dependent Cytotoxicity	T Cell Mediated Immunity Immune Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation T Cell Activation Cytotoxic T Cell Differentiation Regulation Of Immune Response
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Blood protein levels ( 30072576 29875488) Body size at age 10 ( 32376654) Chronotype ( 30696823) Fruit consumption ( 32066663) Morning person ( 30696823)	Blood protein levels ( 30072576)
Interacting Genes		16 interacting genes: C8A C9 CCR2 CD2 CD8A CD9 CHRM4 EGFR FAM209A GNAI3 NCR1 NCR3 SLC13A1 SLC6A8 SMAD4 SRC	17 interacting genes: B2M CACYBP CD3D CD59 CD8B CDK1 HLA-A HLA-B HLA-C HLA-E HLA-G LAT LCK LGALS1 PTPRC SREK1 SRSF1
Entrez ID		966	925
HPRD ID		00117	01737
Ensembl ID		ENSG00000085063	ENSG00000153563
Uniprot IDs		P13987 Q6FHM9	P01732 Q6ZVS2 Q8TAW8
PDB IDs		1CDQ 1CDR 1CDS 1ERG 1ERH 2J8B 2OFS 2UWR 2UX2 4BIK 5IMT 5IMY	1AKJ 1CD8 1Q69 2HP4 3QZW
Enriched GO Terms of Interacting Partners?
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