RGS6 and DMAP1

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		RGS6	DMAP1
Description		regulator of G protein signaling 6	DNA methyltransferase 1 associated protein 1
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GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Extrinsic Component Of Membrane	Swr1 Complex Nucleus Nucleoplasm Replication Fork Cytoplasm Cytosol NuA4 Histone Acetyltransferase Complex
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding	RNA Polymerase II Repressing Transcription Factor Binding Transcription Corepressor Activity Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair DNA Methylation Regulation Of Growth Positive Regulation Of Protein Import Into Nucleus Histone Exchange Histone H4 Acetylation Histone H2A Acetylation Response To Ethanol Negative Regulation Of Transcription, DNA-templated
Pathways		G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	HATs acetylate histones
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Autism spectrum disorder or schizophrenia ( 28540026) Bone mineral density (hip) ( 30172743) C-reactive protein levels ( 30388399 21300955) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cutaneous psoriasis ( 26626624) Economic and political preferences (environmentalism) ( 22566634) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General risk tolerance (MTAG) ( 30643258) Heart rate ( 28610988) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Intracranial aneurysm ( 29531279) Neuroticism ( 29255261) Night sleep phenotypes ( 27126917) Obesity (extreme) ( 21935397) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Resting heart rate ( 29769521 27798624) Schizophrenia ( 28991256 25056061 29483656 30285260) Small cell lung carcinoma ( 28604730) Smoking cessation ( 20811658) Systolic blood pressure ( 30224653 30578418) Transverse temporal cortex volume ( 31530798) Yang-deficiency constitution ( 25533513)	Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: DMAP1 DNMT1 GNB5 STMN2	38 interacting genes: ARFIP2 BFSP2 C1orf216 CCHCR1 CDCA7L DAXX DNMT1 EXOC8 GAS8 GINS4 HDAC2 HSF2BP HSPB1 ING1 KRT75 LMNB1 LRSAM1 MIS18A MNAT1 MORF4L1 MRGBP NAP1L2 PFDN1 PIBF1 RGS6 SAAL1 SBK3 SUOX TCEANC TCHP TLK2 TOMM34 TRIM21 TSG101 TSGA10IP TXLNA TXLNB URI1
Entrez ID		9628	55929
HPRD ID		04871	05465
Ensembl ID		ENSG00000182732	ENSG00000178028
Uniprot IDs		B7Z2A0 B7Z2N1 P49758 Q2M3K2	Q9NPF5
PDB IDs		2ES0	3HM5 4IEJ
Enriched GO Terms of Interacting Partners?
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