RGS6 and GNB5

Data Source:
HPRD (in vivo, in vitro)

		RGS6	GNB5
Description		regulator of G protein signaling 6	G protein subunit beta 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Extrinsic Component Of Membrane	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Presynapse GTPase Activator Complex
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding	GTPase Activity GTPase Activator Activity Protein Binding G-protein Gamma-subunit Binding Chaperone Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity	Protein Folding Signal Transduction G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Positive Regulation Of GTPase Activity Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways		G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Activation of G protein gated Potassium channels G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Autism spectrum disorder or schizophrenia ( 28540026) Bone mineral density (hip) ( 30172743) C-reactive protein levels ( 30388399 21300955) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cutaneous psoriasis ( 26626624) Economic and political preferences (environmentalism) ( 22566634) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General risk tolerance (MTAG) ( 30643258) Heart rate ( 28610988) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Intracranial aneurysm ( 29531279) Neuroticism ( 29255261) Night sleep phenotypes ( 27126917) Obesity (extreme) ( 21935397) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Resting heart rate ( 29769521 27798624) Schizophrenia ( 28991256 25056061 29483656 30285260) Small cell lung carcinoma ( 28604730) Smoking cessation ( 20811658) Systolic blood pressure ( 30224653 30578418) Transverse temporal cortex volume ( 31530798) Yang-deficiency constitution ( 25533513)	Lewy body disease ( 25188341)
Interacting Genes		4 interacting genes: DMAP1 DNMT1 GNB5 STMN2	27 interacting genes: ANXA7 APP BNIP3L CDKN1A CSNK2B DRD2 E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1
Entrez ID		9628	10681
HPRD ID		04871	09191
Ensembl ID		ENSG00000182732	ENSG00000069966
Uniprot IDs		B7Z2A0 B7Z2N1 P49758 Q2M3K2	A0A024R5R9 A0A024R5V3 O14775
PDB IDs		2ES0
Enriched GO Terms of Interacting Partners?
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