SCARB2 and LAPTM4B

Data Source:
BioGRID (two hybrid)

		SCARB2	LAPTM4B
Description		scavenger receptor class B member 2	lysosomal protein transmembrane 4 beta
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Endosome Membrane Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane Endocytic Vesicle Membrane Late Endosome Membrane Lysosomal Lumen Extracellular Exosome	Lysosome Lysosomal Membrane Endosome Early Endosome Plasma Membrane Integral Component Of Membrane Late Endosome Membrane Multivesicular Body Membrane Cell Projection Multivesicular Body, Internal Vesicle
	Molecular Function	Virus Receptor Activity Phosphatidylserine Binding Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Protein Binding Cholesterol Binding Enzyme Binding Phosphatidylcholine Binding Cargo Receptor Activity Protein Homodimerization Activity	Protein Binding Kinase Binding Ubiquitin Protein Ligase Binding Ceramide Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Protein Targeting To Lysosome Receptor-mediated Endocytosis Positive Regulation Of Neuron Projection Development Aminophospholipid Transport Regulation Of Cellular Carbohydrate Catabolic Process Viral Entry Into Host Cell Membrane Organization Regulation Of Endosome Organization Regulation Of Glucosylceramidase Activity Regulation Of Lysosome Organization	Endosome Organization Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Lysosome Organization
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Estimated glomerular filtration rate ( 31015462) Hippocampal volume ( 29274321) Parkinson's disease ( 25064009 21738487) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Metabolite levels ( 23823483) QT interval ( 24952745)
Interacting Genes		10 interacting genes: AP3S1 AP3S2 CLDN19 ERGIC3 GPR37L1 GPX8 HIBADH LAPTM4B LMNA THBS1	21 interacting genes: BDKRB1 CGRRF1 CTXN3 CYB561A3 EMP1 GJA8 GPX8 IFNAR1 IGFBP5 ISLR2 MTIF3 NAALADL2 NRG1 ODF4 PIP5K1C SCARB2 SLC22A1 SLC22A2 SLC29A2 TMEM86B TRARG1
Entrez ID		950	55353
HPRD ID		03772	13960
Ensembl ID		ENSG00000138760	ENSG00000104341
Uniprot IDs		A0A024RDG6 Q14108	Q86VI4
PDB IDs		4F7B 4Q4B 4Q4F 4TVZ 4TW0 4TW2 5UPH 5XBM 6I2K
Enriched GO Terms of Interacting Partners?
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