ARHGEF6 and SH2D1A

Data Source:
HPRD (in vivo, two hybrid)

		ARHGEF6	SH2D1A
Description		Rac/Cdc42 guanine nucleotide exchange factor 6	SH2 domain containing 1A
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GO Annotations	Cellular Component	Cytosol Lamellipodium	Cytoplasm Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Protein Binding
	Biological Process	Apoptotic Process G Protein-coupled Receptor Signaling Pathway JNK Cascade Lamellipodium Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Adaptive Immune Response Humoral Immune Response Cellular Defense Response Cell-cell Signaling Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases		Non-syndromic X-linked mental retardation	Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Breast cancer ( 29059683)
Interacting Genes		37 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 EPHB2 GIT1 GIT2 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580	32 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1
Entrez ID		9459	4068
HPRD ID		02226	02390
Ensembl ID		ENSG00000129675	ENSG00000183918
Uniprot IDs		B7Z3C7 Q15052 Q8N4Q3	O60880
PDB IDs		1UJY 1WYR	1D1Z 1D4T 1D4W 1KA6 1KA7 1M27
Enriched GO Terms of Interacting Partners?
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