ARHGEF6

Description		Rac/Cdc42 guanine nucleotide exchange factor 6
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GO Annotations	Cellular Component	Cytosol Lamellipodium
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Apoptotic Process G Protein-coupled Receptor Signaling Pathway JNK Cascade Lamellipodium Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42
Drugs
Diseases		Non-syndromic X-linked mental retardation
GWAS		Breast cancer ( 29059683)
Novel Interacting Genes		1 novel interacting genes: CDK6
Interacting Genes		37 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 EPHB2 GIT1 GIT2 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580
Entrez ID		9459
HPRD ID		02226
Ensembl ID		ENSG00000129675
Uniprot IDs		B7Z3C7 Q15052 Q8N4Q3
PDB IDs		1UJY 1WYR
Enriched GO Terms of Interacting Partners?
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