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HAND1 and PPP2R5D
Data Source:
BioGRID
(two hybrid)
HPRD
(in vitro)
HAND1
PPP2R5D
Description
heart and neural crest derivatives expressed 1
protein phosphatase 2 regulatory subunit B'delta
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
RNA Polymerase II Transcription Regulator Complex
Protein Phosphatase Type 2A Complex
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coregulator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Transcription Factor Binding
Enzyme Binding
Identical Protein Binding
Protein Homodimerization Activity
BHLH Transcription Factor Binding
Phosphoprotein Phosphatase Activity
Protein Binding
Protein Phosphatase Regulator Activity
Protein Phosphatase Activator Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Mesoderm Formation
Blastocyst Development
Trophectodermal Cell Differentiation
Heart Looping
Embryonic Heart Tube Formation
Cardiac Left Ventricle Formation
Cardiac Right Ventricle Formation
Regulation Of Transcription By RNA Polymerase II
Heart Development
Developmental Process
Embryonic Heart Tube Development
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Ventricular Cardiac Muscle Tissue Morphogenesis
Cardiac Septum Morphogenesis
Mesenchyme Development
Cartilage Morphogenesis
Trophoblast Giant Cell Differentiation
Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Protein Dephosphorylation
Signal Transduction
Nervous System Development
Negative Regulation Of Peptidyl-threonine Phosphorylation
Regulation Of Protein Autophosphorylation
Positive Regulation Of Protein Dephosphorylation
Regulation Of Phosphoprotein Phosphatase Activity
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Chin dimples (
27182965
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic traits (
32602732
)
Global electrical heterogeneity phenotypes (
29622589
)
Monobrow (
27182965
)
QRS complex (Cornell) (
27659466
)
QRS duration (
30679814
27577874
31251759
25035420
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Estimated glomerular filtration rate (
31015462
)
Interacting Genes
15 interacting genes:
ACHE
DNMT3L
FHL2
HAND2
HEY2
HEYL
KRTAP10-6
MEF2A
MYOD1
PPP2R5D
PRKACA
PRKCA
SRA1
TCF12
TCF3
18 interacting genes:
CHEK2
CLOCK
CRY1
CRY2
CSNK1E
CSNK2B
DELEC1
DYDC1
FSD2
HAND1
HAND2
PPFIA1
PPP2R1A
PPP2R1B
PPP4C
RORC
SGO1
USHBP1
Entrez ID
9421
5528
HPRD ID
03871
09039
Ensembl ID
ENSG00000113196
ENSG00000112640
Uniprot IDs
O96004
A0A024RD11
Q14738
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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