IL12A and WASF1

Data Source:
HPRD (in vitro)

		IL12A	WASF1
Description		interleukin 12A	WASP family member 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Late Endosome Lumen Interleukin-12 Complex	Mitochondrial Outer Membrane Cytoskeleton Focal Adhesion Actin Cytoskeleton Lamellipodium SCAR Complex Dendrite Cytoplasm Protein-containing Complex Postsynapse
	Molecular Function	Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Beta Subunit Binding Interleukin-27 Binding Protein Heterodimerization Activity	Actin Binding Protein Binding Small GTPase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Arp2/3 Complex Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response Cell Cycle Arrest Response To Virus Response To UV-B Viral Process Cell Migration Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Interleukin-12-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Negative Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Positive Regulation Of NK T Cell Activation Interleukin-35-mediated Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cellular Response To Virus Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Dendritic Cell Chemotaxis	Receptor-mediated Endocytosis Rac Protein Signal Transduction Actin Cytoskeleton Organization Actin Filament Polymerization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein-containing Complex Assembly Mitochondrion Morphogenesis Lamellipodium Morphogenesis Dendrite Extension Modification Of Postsynaptic Actin Cytoskeleton Dendritic Transport Of Mitochondrion Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Behcet's disease ( 23291587 27548383 25799145) Bipolar disorder ( 31043756) Celiac disease ( 22057235 20190752 25920553 18311140) Limited cutaneous systemic scleroderma ( 24387989) Major depressive disorder ( 23377640) Multiple sclerosis ( 24076602 19525953 21833088) Primary biliary cholangitis ( 28425483 19458352 21399635 20639880 26394269 28062665) Primary biliary cirrhosis ( 22961000) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic sclerosis ( 24387989 31672989)
Interacting Genes		5 interacting genes: CD28 CXCL8 EBI3 IL12B WASF1	40 interacting genes: ABI1 ABI3 ABL1 ACTB ACTG1 ACTR2 ACTR3 BAD BAIAP2 BRK1 CCDC196 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP EFHC1 FYN GNAI1 GRB2 HSF2BP IFT20 IL12A ING5 LMO2 MAPKAPK2 NCK1 NCK2 NCKAP1 NYAP2 OSTF1 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRAF2 TRIP10
Entrez ID		3592	8936
HPRD ID		01193	05434
Ensembl ID		ENSG00000168811	ENSG00000112290
Uniprot IDs		O60595 P29459	Q92558
PDB IDs		1F45 3HMX	3P8C 4N78
Enriched GO Terms of Interacting Partners?
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