TRIP12 and SOX6

Data Source:
BioGRID (two hybrid, affinity chromatography technology, enzymatic study)

		TRIP12	SOX6
Description		thyroid hormone receptor interactor 12	SRY-box transcription factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Embryonic Development Negative Regulation Of Histone H2A K63-linked Ubiquitination Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair	Cartilage Condensation Chondrocyte Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Muscle Organ Development Spinal Cord Oligodendrocyte Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Astrocyte Differentiation Cartilage Development Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Estimated glomerular filtration rate ( 31152163 31015462) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Weight ( 28552196)	Adolescent idiopathic scoliosis ( 30395268) Anti-saccade response ( 25387707) Blond vs. brown/black hair color ( 30531825) Blood pressure ( 23972371) Bone mineral density ( 24249740) Bone mineral density (hip) ( 19801982) Bone mineral density (wrist) ( 21104366) Capecitabine sensitivity ( 22864933) Chronotype ( 30696823) Coronary artery disease ( 29212778 33020668) Cotinine glucuronidation ( 25293881) Diastolic blood pressure ( 27841878 25249183 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Experiencing mood swings ( 29500382) Femoral neck bone mineral density ( 29499414 32239398 26367794 22504420) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) General factor of neuroticism ( 30867560) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hypertension ( 25249183) Left-handedness ( 32989287) Longevity (90 years and older) ( 25199915) Lumbar spine bone mineral density ( 26367794) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 29403010 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Multisite chronic pain ( 31194737) Neurociticism ( 29500382) Neuroticism ( 29255261) Obesity and osteoporosis ( 19714249) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systolic blood pressure ( 27841878 25249183 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tea consumption ( 31046077)
Interacting Genes		20 interacting genes: ATF7IP CARNS1 CDKN2A CELSR3 CLSTN1 ERG MTNR1A MTNR1B NAE1 NMI PTF1A SMAD9 SOX6 SRPK2 THRB UBC UBE2D1 UBE2D2 UBE2L3 UBE4B	12 interacting genes: CENPK CTBP2 DAZAP2 HDAC1 POMGNT1 SOX5 SUMO1 SUMO2 SUMO3 TRIP12 UBE2I ZNF184
Entrez ID		9320	55553
HPRD ID		05144	06267
Ensembl ID		ENSG00000153827	ENSG00000110693
Uniprot IDs		A0A6Q8PGG9 A0A6Q8PHK0 Q14669	P35712
PDB IDs
Enriched GO Terms of Interacting Partners?
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