TRIP12 and UBE4B

Data Source:
BioGRID (pull down)

		TRIP12	UBE4B
Description		thyroid hormone receptor interactor 12	ubiquitination factor E4B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	Protein Binding Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	Enzyme Binding Ubiquitin-ubiquitin Ligase Activity ATPase Binding
	Biological Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Embryonic Development Negative Regulation Of Histone H2A K63-linked Ubiquitination Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Granzyme-mediated Apoptotic Signaling Pathway Response To UV Ubiquitin-dependent ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Estimated glomerular filtration rate ( 31152163 31015462) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Weight ( 28552196)	Atrial fibrillation ( 29892015) Hepatocellular carcinoma ( 20676096) Resting heart rate ( 27798624)
Interacting Genes		20 interacting genes: ATF7IP CARNS1 CDKN2A CELSR3 CLSTN1 ERG MTNR1A MTNR1B NAE1 NMI PTF1A SMAD9 SOX6 SRPK2 THRB UBC UBE2D1 UBE2D2 UBE2L3 UBE4B	22 interacting genes: ATXN3 CASP3 CASP6 CASP7 CDKN2A DNAJC7 ESR1 FEZ1 GZMB HGS HRAS MAPK3 OTUB1 PGAM5 PPP3CA PRMT1 RAD23A TRIP12 UBE2D2 UBE2D3 VAV2 VCP
Entrez ID		9320	10277
HPRD ID		05144	11659
Ensembl ID		ENSG00000153827	ENSG00000130939
Uniprot IDs		A0A6Q8PGG9 A0A6Q8PHK0 Q14669	O95155
PDB IDs			2KRE 3L1X 3L1Z 5O75
Enriched GO Terms of Interacting Partners?
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