COPS2 and MAP3K10

Data Source:
BioGRID (pull down, enzymatic study)

		COPS2	MAP3K10
Description		COP9 signalosome subunit 2	mitogen-activated protein kinase kinase kinase 10
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol COP9 Signalosome	Cytoplasm
	Molecular Function	Protein Binding NEDD8-specific Protease Activity	Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity ATP Binding Protein Homodimerization Activity BHLH Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Inner Cell Mass Cell Proliferation Transcription-coupled Nucleotide-excision Repair Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Neuron Differentiation Skeletal Muscle Cell Differentiation Post-translational Protein Modification Negative Regulation Of Nucleic Acid-templated Transcription	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs			Fostamatinib
Diseases
GWAS		Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)	Birth weight ( 31043758) Resting heart rate ( 27798624)
Interacting Genes		38 interacting genes: COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CSNK2A1 CUL5 DDB1 EP300 GFER GPS1 H3C1 H4C1 ING1 ING2 IP6K1 IRF8 MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 PRKD1 PSMD11 RARA RND1 RXRA SENP8 SIN3A SIN3B THRA THRB TP53 VDR ZNF446	31 interacting genes: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS1 HGS HTT KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP3K21 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB RAC1 RACGAP1 SH3RF1 SMURF1 TUBB YWHAE
Entrez ID		9318	4294
HPRD ID		05146	02533
Ensembl ID		ENSG00000166200	ENSG00000130758
Uniprot IDs		P61201 Q59EL2	Q02779
PDB IDs		4D10 4D18 4WSN 6A73 6R6H 6R7F 6R7H 6R7I 6R7N	2RF0
Enriched GO Terms of Interacting Partners?
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