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SHKBP1 and CUL3
Data Source:
BioGRID
(pull down, two hybrid, affinity chromatography technology, two hybrid)
SHKBP1
CUL3
Description
SH3KBP1 binding protein 1
cullin 3
Image
GO Annotations
Cellular Component
Lysosome
Golgi Membrane
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Polar Microtubule
Cytosol
Plasma Membrane
Membrane
Cullin-RING Ubiquitin Ligase Complex
Cul3-RING Ubiquitin Ligase Complex
Sperm Flagellum
Extracellular Exosome
Mitotic Spindle
Molecular Function
Protein Binding
Identical Protein Binding
Ubiquitin-protein Transferase Activity
Notch Binding
Protein Binding
Cyclin Binding
POZ Domain Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Biological Process
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Protein Homooligomerization
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Protein Polyubiquitination
Trophectodermal Cellular Morphogenesis
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Mitotic Metaphase Plate Congression
Integrin-mediated Signaling Pathway
Gastrulation
Positive Regulation Of Cell Population Proliferation
Wnt Signaling Pathway
Cell Migration
Protein Ubiquitination
Stem Cell Division
Cell Projection Organization
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Positive Regulation Of Cytokinesis
Negative Regulation Of Rho Protein Signal Transduction
Embryonic Cleavage
Stress Fiber Assembly
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Fibroblast Apoptotic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
COPII Vesicle Coating
Protein Autoubiquitination
Nuclear Protein Quality Control By The Ubiquitin-proteasome System
Liver Morphogenesis
Negative Regulation Of Canonical Wnt Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Degradation of DVL
Hedgehog 'on' state
Regulation of RAS by GAPs
Neddylation
RHOBTB2 GTPase cycle
RHOBTB1 GTPase cycle
RHOBTB3 ATPase cycle
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Carotid intima media thickness (mean) (
31801372
)
Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) (
31372216
)
Hemoglobin levels (
32327693
)
Acute graft versus host disease in bone marrow transplantation (recipient effect) (
27595289
)
General risk tolerance (MTAG) (
30643258
)
Response to bupropion and depression (
27622933
)
Schizophrenia (
28991256
25056061
29483656
30285260
)
Sensorimotor dexterity (
31596458
)
Thrombin-activatable fibrinolysis inhibitor activation peptide (
29378355
)
Interacting Genes
10 interacting genes:
CCNG1
COL7A1
CUL3
GRB2
LXN
NR3C1
PIN1
PRPF3
SH3KBP1
YWHAG
78 interacting genes:
ABTB1
ABTB2
ACLY
APP
ARHGEF12
BTBD1
BTBD10
BTBD2
BTBD3
BTBD6
CAMK1D
CAND1
CCND1
CCNE1
CDC25A
CDC34
CLK1
COMMD1
COPS5
DCUN1D2
DCUN1D3
DCUN1D4
DCUN1D5
DYRK4
EFNB1
ELOC
FOLR1
GABARAP
GABARAPL1
GABARAPL2
GMCL1
GPS1
HLA-DMB
HSF2
KCTD10
KCTD11
KCTD13
KCTD17
KCTD5
KCTD6
KCTD7
KCTD9
KEAP1
KLHL12
KLHL2
KLHL3
KLHL42
MAP1LC3B
MAP1LC3C
MAT2A
MTNR1A
MTNR1B
NEDD8
OLIG2
PDCD6
PDIA2
PEF1
RBBP8
RBX1
RCBTB1
RCBTB2
RHOBTB3
RIT1
RNF7
SHKBP1
SPOP
SUMO2
SUMO3
UBASH3B
UBC
UBE2D1
UBE2D2
UBE2E1
UBE2E2
UBE2E3
UBE2R2
WNT7B
ZMAT4
Entrez ID
92799
8452
HPRD ID
15338
09123
Ensembl ID
ENSG00000160410
ENSG00000036257
Uniprot IDs
B3KVX8
Q8TBC3
A0A024R475
B7Z600
Q13618
PDB IDs
4CRH
2MYL
2MYM
4AP2
4APF
4EOZ
4HXI
5NLB
6I2M
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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