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CUL3 and CCNE1
Data Source:
HPRD
(in vitro, two hybrid, in vivo)
CUL3
CCNE1
Description
cullin 3
cyclin E1
Image
GO Annotations
Cellular Component
Golgi Membrane
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Polar Microtubule
Cytosol
Plasma Membrane
Membrane
Cullin-RING Ubiquitin Ligase Complex
Cul3-RING Ubiquitin Ligase Complex
Sperm Flagellum
Extracellular Exosome
Mitotic Spindle
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Cyclin E1-CDK2 Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Notch Binding
Protein Binding
Cyclin Binding
POZ Domain Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Protein Polyubiquitination
Trophectodermal Cellular Morphogenesis
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Mitotic Metaphase Plate Congression
Integrin-mediated Signaling Pathway
Gastrulation
Positive Regulation Of Cell Population Proliferation
Wnt Signaling Pathway
Cell Migration
Protein Ubiquitination
Stem Cell Division
Cell Projection Organization
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Positive Regulation Of Cytokinesis
Negative Regulation Of Rho Protein Signal Transduction
Embryonic Cleavage
Stress Fiber Assembly
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Fibroblast Apoptotic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
COPII Vesicle Coating
Protein Autoubiquitination
Nuclear Protein Quality Control By The Ubiquitin-proteasome System
Liver Morphogenesis
Negative Regulation Of Canonical Wnt Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Telomere Maintenance
DNA Replication Initiation
Protein Phosphorylation
Homologous Chromosome Pairing At Meiosis
Wnt Signaling Pathway
Mitotic Cell Cycle Phase Transition
Cell Division
Positive Regulation Of Mesenchymal Stem Cell Proliferation
Regulation Of Cellular Protein Localization
Pathways
Degradation of DVL
Hedgehog 'on' state
Regulation of RAS by GAPs
Neddylation
RHOBTB2 GTPase cycle
RHOBTB1 GTPase cycle
RHOBTB3 ATPase cycle
Antigen processing: Ubiquitination & Proteasome degradation
G0 and Early G1
SCF(Skp2)-mediated degradation of p27/p21
DNA Damage/Telomere Stress Induced Senescence
Association of TriC/CCT with target proteins during biosynthesis
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDK-mediated phosphorylation and removal of Cdc6
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
PTK6 Regulates Cell Cycle
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
RHOBTB3 ATPase cycle
Drugs
Diseases
Laryngeal cancer
Gastric cancer
GWAS
Acute graft versus host disease in bone marrow transplantation (recipient effect) (
27595289
)
General risk tolerance (MTAG) (
30643258
)
Response to bupropion and depression (
27622933
)
Schizophrenia (
28991256
25056061
29483656
30285260
)
Sensorimotor dexterity (
31596458
)
Thrombin-activatable fibrinolysis inhibitor activation peptide (
29378355
)
Adult body size (
32376654
)
Bladder cancer (
24163127
20972438
)
Body mass index (
25673413
)
Breast cancer (
29058716
)
Breast cancer (estrogen-receptor negative) (
29058716
)
Diastolic blood pressure (
28135244
27841878
)
Medication use (diuretics) (
31015401
)
Response to fenofibrate (total cholesterol levels) (
27002377
)
Spatial processing (
31596458
)
Interacting Genes
78 interacting genes:
ABTB1
ABTB2
ACLY
APP
ARHGEF12
BTBD1
BTBD10
BTBD2
BTBD3
BTBD6
CAMK1D
CAND1
CCND1
CCNE1
CDC25A
CDC34
CLK1
COMMD1
COPS5
DCUN1D2
DCUN1D3
DCUN1D4
DCUN1D5
DYRK4
EFNB1
ELOC
FOLR1
GABARAP
GABARAPL1
GABARAPL2
GMCL1
GPS1
HLA-DMB
HSF2
KCTD10
KCTD11
KCTD13
KCTD17
KCTD5
KCTD6
KCTD7
KCTD9
KEAP1
KLHL12
KLHL2
KLHL3
KLHL42
MAP1LC3B
MAP1LC3C
MAT2A
MTNR1A
MTNR1B
NEDD8
OLIG2
PDCD6
PDIA2
PEF1
RBBP8
RBX1
RCBTB1
RCBTB2
RHOBTB3
RIT1
RNF7
SHKBP1
SPOP
SUMO2
SUMO3
UBASH3B
UBC
UBE2D1
UBE2D2
UBE2E1
UBE2E2
UBE2E3
UBE2R2
WNT7B
ZMAT4
70 interacting genes:
AKT1
AR
ARHGEF5
ARID4A
ARIH1
ARNT
AURKA
BRCA2
BTRC
CABLES1
CALM1
CCND2
CCT4
CDC25A
CDC6
CDK1
CDK2
CDK3
CDK4
CDK6
CDKN1A
CDKN1B
CDKN2A
CDKN2B
CDKN2C
COIL
CUL3
FBXW7
FGFR4
FOXM1
FZR1
GLIS2
GMNC
GRM1
GSK3B
H1-0
H1-1
H1-5
HERC5
KAT2A
LATS2
MARCKS
MCM3
MRE11
MYBL2
MYC
NBN
NF2
PIN1
POLD1
PRC1
PRKAR1A
PTPA
RASSF1
RB1
RBL1
RBL2
REL
RHOBTB3
RRN3
SKP2
SMARCA4
SMARCC1
SMARCD3
SPOP
STK11
TERT
TP73
TSC1
UBTF
Entrez ID
8452
898
HPRD ID
09123
00455
Ensembl ID
ENSG00000036257
ENSG00000105173
Uniprot IDs
A0A024R475
B7Z600
Q13618
A0A0G3DHS8
P24864
V5W5X2
PDB IDs
2MYL
2MYM
4AP2
4APF
4EOZ
4HXI
5NLB
6I2M
1W98
5L2W
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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