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RPS6KA5 and BAD
Data Source:
HPRD
(in vitro)
RPS6KA5
BAD
Description
ribosomal protein S6 kinase A5
BCL2 associated agonist of cell death
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Molecular Function
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protein Binding
Phospholipid Binding
Lipid Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Protein Kinase Binding
Protein Phosphatase Binding
Protein Phosphatase 2B Binding
Protein Kinase B Binding
14-3-3 Protein Binding
Biological Process
Negative Regulation Of Cytokine Production
Stimulatory C-type Lectin Receptor Signaling Pathway
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Inflammatory Response
Epidermal Growth Factor Receptor Signaling Pathway
Axon Guidance
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Positive Regulation Of CREB Transcription Factor Activity
Positive Regulation Of Histone Phosphorylation
Positive Regulation Of Histone Acetylation
Intracellular Signal Transduction
Histone H3-S10 Phosphorylation
Histone H3-S28 Phosphorylation
Histone H2A-S1 Phosphorylation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of NF-kappaB Transcription Factor Activity
Interleukin-1-mediated Signaling Pathway
Release Of Cytochrome C From Mitochondria
Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Glucose Catabolic Process
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Spermatogenesis
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Glucose
Positive Regulation Of Autophagy
Positive Regulation Of Mitochondrial Membrane Potential
Suppression By Virus Of Host Apoptotic Process
Cytokine-mediated Signaling Pathway
Cerebral Cortex Development
Positive Regulation Of Insulin Secretion
Response To Estradiol
Response To Progesterone
Positive Regulation Of Glucokinase Activity
Response To Testosterone
Response To Oleic Acid
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Response To Drug
Response To Hydrogen Peroxide
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Response To Amino Acid
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Type B Pancreatic Cell Proliferation
Response To Ethanol
Positive Regulation Of B Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Proteolysis
ADP Metabolic Process
ATP Metabolic Process
Regulation Of Mitochondrial Membrane Permeability
Pore Complex Assembly
Positive Regulation Of Epithelial Cell Proliferation
Response To Glucocorticoid
Response To Calcium Ion
Positive Regulation Of Apoptotic Process By Virus
Cellular Response To Chromate
Cellular Response To Mechanical Stimulus
Cellular Response To Nicotine
Cellular Response To Lipid
Cellular Response To Hypoxia
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Activation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Neuron Death
Response To Benzene
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Positive Regulation Of Granulosa Cell Apoptotic Process
Positive Regulation Of Type B Pancreatic Cell Development
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
ERK/MAPK targets
CREB phosphorylation
NCAM signaling for neurite out-growth
Recycling pathway of L1
CD209 (DC-SIGN) signaling
Activation of BAD and translocation to mitochondria
Activation of BAD and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
NRAGE signals death through JNK
AKT phosphorylates targets in the cytosol
Constitutive Signaling by AKT1 E17K in Cancer
Drugs
Navitoclax
Diseases
GWAS
Adult body size (
32376654
)
Bitter alcoholic beverage consumption (
31046077
)
Femoral neck bone mineral density (
29499414
22504420
)
Fractures (
30158200
)
Heel bone mineral density (
30598549
)
Lumbar spine bone mineral density (
29499414
)
Multiple sclerosis (
31604244
)
Proportion of activated microglia (inferior temporal cortex) (
30679421
)
Response to platinum-based neoadjuvant chemotherapy in cervical cancer (
28120872
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Crohn's disease (
28067908
)
Heel bone mineral density (
30598549
)
Platelet count (
22423221
)
Sarcoidosis (
22837380
)
Vitiligo (
27723757
)
Interacting Genes
60 interacting genes:
ACTG1
AKT1S1
ALG8
APP
ATF1
ATF2
BAD
CEBPB
CREB1
CREBBP
CRMP1
CSNK2B
CTNNA3
DDAH2
DNAJC11
EIF4EBP1
EP300
ERH
ETV1
EZH2
FN1
GPRASP2
H1-1
H1-5
H2AW
H2BC21
H2BC3
H2BU1
H3-4
H3C14
H3C6
H4-16
H4C14
HMGN1
HSPB2
IL17RB
ITSN1
MAP3K20
MAPK11
MAPK14
MAPT
MBP
MDFIC
NR4A1
PDLIM1
PLA2G4A
RAI1
RELA
RNF19A
ROBO2
RPA1
SMAD6
SMARCB1
STAT1
STAT3
STK11
TH
TXNDC11
UNC119
ZNF775
45 interacting genes:
ACTN2
AKT1
ARAF
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L2
BRAF
CDKN1A
CREB3L3
EWSR1
HRK
KEAP1
KRT31
MAP2K5
MAPK8
MCL1
PAK1
PAK5
PIM1
PIM2
PIM3
PPP1CA
PPP3CA
PRDX2
PRKACA
PRKCI
RAF1
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA5
S100A10
SFN
SNCA
STEAP3
SUMO2
WASF1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
9252
572
HPRD ID
06789
04409
Ensembl ID
ENSG00000100784
ENSG00000002330
Uniprot IDs
O75582
A0A024R562
Q92934
PDB IDs
1VZO
3KN5
3KN6
1G5J
Enriched GO Terms of Interacting Partners
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