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RPS6KA5 and ATF2
Data Source:
HPRD
(in vitro)
RPS6KA5
ATF2
Description
ribosomal protein S6 kinase A5
activating transcription factor 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Outer Membrane
Site Of Double-strand Break
H4 Histone Acetyltransferase Complex
Molecular Function
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Activating Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Histone Acetyltransferase Activity
Protein Binding
CAMP Response Element Binding Protein Binding
H4 Histone Acetyltransferase Activity
Protein Kinase Binding
CAMP Response Element Binding
H2B Histone Acetyltransferase Activity
Protein-containing Complex Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Cytokine Production
Stimulatory C-type Lectin Receptor Signaling Pathway
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Inflammatory Response
Epidermal Growth Factor Receptor Signaling Pathway
Axon Guidance
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Positive Regulation Of CREB Transcription Factor Activity
Positive Regulation Of Histone Phosphorylation
Positive Regulation Of Histone Acetylation
Intracellular Signal Transduction
Histone H3-S10 Phosphorylation
Histone H3-S28 Phosphorylation
Histone H2A-S1 Phosphorylation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of NF-kappaB Transcription Factor Activity
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Outflow Tract Morphogenesis
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Response To Osmotic Stress
Cellular Response To DNA Damage Stimulus
Response To Water Deprivation
Positive Regulation Of Gene Expression
Negative Regulation Of Angiogenesis
Intra-S DNA Damage Checkpoint
Positive Regulation Of Transforming Growth Factor Beta2 Production
Positive Regulation Of Neuron Apoptotic Process
Histone H4 Acetylation
Histone H2B Acetylation
Fat Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Epithelial Cell Proliferation
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of DNA-binding Transcription Factor Activity
Adipose Tissue Development
Amelogenesis
Positive Regulation Of Cardiac Muscle Myoblast Proliferation
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways
ERK/MAPK targets
CREB phosphorylation
NCAM signaling for neurite out-growth
Recycling pathway of L1
CD209 (DC-SIGN) signaling
Transcriptional activation of mitochondrial biogenesis
HATs acetylate histones
Circadian Clock
Activation of the AP-1 family of transcription factors
TP53 Regulates Transcription of DNA Repair Genes
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
NGF-stimulated transcription
NGF-stimulated transcription
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK4 (GCN2) to amino acid deficiency
Drugs
Pseudoephedrine
Diseases
GWAS
Adult body size (
32376654
)
Bitter alcoholic beverage consumption (
31046077
)
Femoral neck bone mineral density (
29499414
22504420
)
Fractures (
30158200
)
Heel bone mineral density (
30598549
)
Lumbar spine bone mineral density (
29499414
)
Multiple sclerosis (
31604244
)
Proportion of activated microglia (inferior temporal cortex) (
30679421
)
Response to platinum-based neoadjuvant chemotherapy in cervical cancer (
28120872
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Intake of total sugars (
31005972
)
Metabolite levels (
23823483
)
Interacting Genes
60 interacting genes:
ACTG1
AKT1S1
ALG8
APP
ATF1
ATF2
BAD
CEBPB
CREB1
CREBBP
CRMP1
CSNK2B
CTNNA3
DDAH2
DNAJC11
EIF4EBP1
EP300
ERH
ETV1
EZH2
FN1
GPRASP2
H1-1
H1-5
H2AW
H2BC21
H2BC3
H2BU1
H3-4
H3C14
H3C6
H4-16
H4C14
HMGN1
HSPB2
IL17RB
ITSN1
MAP3K20
MAPK11
MAPK14
MAPT
MBP
MDFIC
NR4A1
PDLIM1
PLA2G4A
RAI1
RELA
RNF19A
ROBO2
RPA1
SMAD6
SMARCB1
STAT1
STAT3
STK11
TH
TXNDC11
UNC119
ZNF775
63 interacting genes:
APP
AR
ATF3
ATF4
ATF7
BACH1
BANP
BATF
CCDC6
CCND1
CEBPA
CEBPB
CEBPG
CENPQ
CREB5
CSNK2A1
CSNK2A2
DDIT3
DNMT3L
EDF1
ETS1
EXOSC8
FOS
FOSB
FOSL1
FOSL2
GTF2F2
H2BC21
HMGA1
IRF2BP1
JDP2
JUN
KIFC3
LHX8
MACROH2A1
MAPK1
MAPK10
MAPK11
MAPK13
MAPK14
MAPK8
MAPK9
MAPKAPK5
MLH1
NBN
NCOA6
PIAS2
PML
PRKCE
RB1
RNF4
RPS6KA5
RUVBL2
SMAD3
SMAD4
SPOPL
SRA1
SUMO1
THRB
UBE2I
UTF1
XPO1
YY1
Entrez ID
9252
1386
HPRD ID
06789
00443
Ensembl ID
ENSG00000100784
ENSG00000115966
Uniprot IDs
O75582
A4D7V5
P15336
PDB IDs
1VZO
3KN5
3KN6
1BHI
1T2K
4H36
Enriched GO Terms of Interacting Partners
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