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CD5L and CD40LG
Data Source:
HPRD
(in vivo)
CD5L
CD40LG
Description
CD5 molecule like
CD40 ligand
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytoplasm
Plasma Membrane
Cell Surface
Blood Microparticle
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Integral Component Of Membrane
Molecular Function
Serine-type Endopeptidase Activity
Scavenger Receptor Activity
Cytokine Activity
Tumor Necrosis Factor Receptor Binding
CD40 Receptor Binding
Integrin Binding
Protein Binding
Biological Process
Immune System Process
Endocytosis
Apoptotic Process
Inflammatory Response
Cellular Defense Response
Regulation Of Complement Activation
Zymogen Activation
Positive Regulation Of Complement-dependent Cytotoxicity
Regulation Of Immunoglobulin Production
Inflammatory Response
Leukocyte Cell-cell Adhesion
Integrin-mediated Signaling Pathway
Activation Of JUN Kinase Activity
CD40 Signaling Pathway
Platelet Activation
B Cell Differentiation
T Cell Costimulation
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-4 Production
Tumor Necrosis Factor-mediated Signaling Pathway
B Cell Proliferation
Positive Regulation Of T Cell Proliferation
Negative Regulation Of Apoptotic Process
Isotype Switching
Regulation Of Immune Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Ruplizumab
Diseases
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS
CD40 ligand levels (
25147954
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Pediatric autoimmune diseases (
26301688
)
Plateletcrit (
32888494
)
Interacting Genes
1 interacting genes:
CD40LG
6 interacting genes:
CD40
CD5L
IGHG1
IGKC
RNF128
TP53
Entrez ID
922
959
HPRD ID
03997
02311
Ensembl ID
ENSG00000073754
ENSG00000102245
Uniprot IDs
O43866
P29965
PDB IDs
1ALY
1I9R
3LKJ
3QD6
6BRB
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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