AP4M1 and ARF1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		AP4M1	ARF1
Description		adaptor related protein complex 4 subunit mu 1	ADP ribosylation factor 1
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GO Annotations	Cellular Component	Early Endosome Trans-Golgi Network Cytosol AP-4 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Endosome Lumen Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Golgi Membrane Cytoplasm Late Endosome Peroxisomal Membrane Trans-Golgi Network Cytosol Plasma Membrane Focal Adhesion Postsynaptic Density Sarcomere COPI-coated Vesicle Cell Leading Edge Protein-containing Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Domain Specific Binding	Magnesium Ion Binding RNA Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Phospholipase D Activator Activity
	Biological Process	Protein Targeting Protein Targeting To Lysosome Intracellular Protein Transport Golgi To Endosome Transport Protein Localization Vesicle-mediated Transport Golgi To Lysosome Transport Protein Localization To Basolateral Plasma Membrane	Regulation Of Receptor Internalization Phosphatidylinositol Biosynthetic Process Cellular Copper Ion Homeostasis Intracellular Protein Transport Actin Filament Organization Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Arp2/3 Complex-mediated Actin Nucleation Very-low-density Lipoprotein Particle Assembly Interleukin-12-mediated Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Defense Response To Virus By Virus Positive Regulation Of Protein Secretion Regulation Of Catalytic Activity Golgi To Transport Vesicle Transport Long-term Synaptic Depression Positive Regulation Of Dendritic Spine Development Synaptic Vesicle Budding Dendritic Spine Organization Lysosomal Membrane Organization Cellular Response To Virus Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Phospholipid Metabolic Process Mitotic Cleavage Furrow Ingression
Pathways		Lysosome Vesicle Biogenesis	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Nef Mediated CD4 Down-regulation trans-Golgi Network Vesicle Budding MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			1,3-Propanediol Guanosine-3'-monophosphate-5'-diphosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Brefeldin A Myristic acid Glycerin
Diseases		Cerebral palsy
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Adolescent idiopathic scoliosis ( 31417091)
Interacting Genes		14 interacting genes: AP4B1 ARF1 CACNG3 CD63 CHTF8 DDX52 FNTA GRID2 GRIN2A GRIN2B LAMP2 TGOLN2 USP47 ZBTB22	47 interacting genes: AGAP1 AGAP2 AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 DUX4 EEF1G ERBB2 GGA1 GGA2 GGA3 GORAB GOSR2 HTR2A INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA SCYL1 TMED10 TMED2 TMEM106A WBP11
Entrez ID		9179	375
HPRD ID		03803	00054
Ensembl ID		ENSG00000221838	ENSG00000143761
Uniprot IDs		C9JC87 O00189	A0A024R3Q0 P84077
PDB IDs		3L81 4MDR	1HUR 1RE0 1U81 3O47 4HMY 6CM9 6CRI 6D83 6D84 6DFF 6FAE
Enriched GO Terms of Interacting Partners?
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