CD2 and CD58

Data Source:
BioGRID (x-ray crystallography, pull down)
HPRD (in vitro)

		CD2	CD58
Description		CD2 molecule	CD58 molecule
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Protein-containing Complex Membrane Raft Anchored Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding Protein Self-association	Signaling Receptor Binding Protein Binding
	Biological Process	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Leukocyte Migration Cell-cell Adhesion	Positive Regulation Of Interleukin-8 Production Heterotypic Cell-cell Adhesion Neutrophil Degranulation Leukocyte Migration Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion
Pathways		Cell surface interactions at the vascular wall	Cell surface interactions at the vascular wall Neutrophil degranulation
Drugs		Alefacept Siplizumab
Diseases
GWAS		Body mass index ( 28552196) Gout (normal type) ( 32238385) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Multiple sclerosis ( 31604244 22190364 21244703 24076602 19525953 19525955 21833088 27386562) Primary biliary cholangitis ( 28425483) Systemic lupus erythematosus ( 33536424)
Interacting Genes		21 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1 UBC	4 interacting genes: APP CD2 DNAJA1 HERPUD1
Entrez ID		914	965
HPRD ID		01750	01081
Ensembl ID		ENSG00000116824	ENSG00000116815
Uniprot IDs		P06729 Q53F96	P19256
PDB IDs		1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I	1CCZ 1CI5 1QA9
Enriched GO Terms of Interacting Partners?
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