CD2 and CD2BP2

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		CD2	CD2BP2
Description		CD2 molecule	CD2 cytoplasmic tail binding protein 2
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Protein-containing Complex Membrane Raft Anchored Component Of Plasma Membrane	Fibrillar Center Nucleus Nucleoplasm U5 SnRNP Cytoplasm Cytosol Nuclear Speck U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding Protein Self-association	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Leukocyte Migration Cell-cell Adhesion	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome Negative Regulation Of Phosphatase Activity
Pathways		Cell surface interactions at the vascular wall	mRNA Splicing - Major Pathway
Drugs		Alefacept Siplizumab
Diseases
GWAS		Body mass index ( 28552196) Gout (normal type) ( 32238385) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		21 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1 UBC	14 interacting genes: ACAD11 AKNA CD2 CHRM3 CSNK2A1 LRRK1 PRPF6 PSMF1 SMU1 SNRPB TRAPPC6A TXNL4A WBP11 ZNHIT2
Entrez ID		914	10421
HPRD ID		01750	05127
Ensembl ID		ENSG00000116824	ENSG00000169217
Uniprot IDs		P06729 Q53F96	A0A024QZC1 O95400
PDB IDs		1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I	1GYF 1L2Z 1SYX 4BWS
Enriched GO Terms of Interacting Partners?
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