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PRC1 and PKIA
Data Source:
BioGRID
(two hybrid)
PRC1
PKIA
Description
protein regulator of cytokinesis 1
cAMP-dependent protein kinase inhibitor alpha
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Spindle
Cytosol
Spindle Microtubule
Plasma Membrane
Microtubule Cytoskeleton
Midbody
Intercellular Bridge
Contractile Ring
Mitotic Spindle Midzone
Nucleus
Cytoplasm
Molecular Function
Protein Binding
Microtubule Binding
Kinesin Binding
Protein Kinase Binding
CAMP-dependent Protein Kinase Inhibitor Activity
Protein Binding
Protein Kinase A Catalytic Subunit Binding
Biological Process
Mitotic Spindle Elongation
Microtubule Cytoskeleton Organization
Microtubule Bundle Formation
Positive Regulation Of Cell Population Proliferation
Regulation Of Cytokinesis
Mitotic Spindle Midzone Assembly
Cell Division
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways
RHO GTPases activate CIT
Drugs
3,5-Diiodotyrosine
Hydroxyfasudil
(2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine
(1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE
(1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE
(4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE
N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
(S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE
(2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
(2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
H-89
5-(2-methylpiperazine-1-sulfonyl)isoquinoline
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
3-pyridin-4-yl-1H-indazole
5-benzyl-1,3-thiazol-2-amine
1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium
Fasudil
Myristic acid
A-674563
3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE
Y-27632
Diseases
GWAS
Breast cancer (
29059683
25038754
)
Mean platelet volume (
32888494
27863252
)
Multisite chronic pain (
31194737
)
Red cell distribution width (
32888494
)
Type 2 diabetes (
22885922
24509480
30054458
30297969
26818947
32499647
20581827
30718926
28869590
)
Femoral neck bone mineral density (
22504420
)
Intraocular pressure (
29617998
31959993
)
Multiple sclerosis (
21833088
)
Optic disc size (
31809533
)
Systemic lupus erythematosus (
28714469
)
Systolic blood pressure response to hydrochlorothiazide in hypertension (
27802415
)
Interacting Genes
29 interacting genes:
AKAP9
CASK
CCDC85B
CCNA2
CCNB1
CCNE1
CDK1
CDK2
CINP
FXR2
KIF3B
KIF4A
KLC2
KLC4
KRT20
MAT2A
NDEL1
PCM1
PKIA
PLK1
RACGAP1
RBM10
RPA2
SF3B2
SLAIN1
SUMO2
TRIM37
USHBP1
YWHAE
12 interacting genes:
AGFG1
CASP6
DYNLL1
DYNLL2
EGFR
JUNB
MRNIP
PRC1
PRKACA
PRKACB
PRKX
XPO1
Entrez ID
9055
5569
HPRD ID
17899
05828
Ensembl ID
ENSG00000198901
ENSG00000171033
Uniprot IDs
A0A024RC67
O43663
A0A024R7Y9
P61925
PDB IDs
3NRX
3NRY
4L3I
4L6Y
5KMG
1CMK
1JLU
1Q8T
1VEB
1XH4
1XH5
1XH6
1XH7
1XH8
1XH9
1XHA
1YDR
2C1A
2C1B
2F7E
2GNI
2JDS
2JDT
2JDV
2L1L
2UVX
2UVY
2UVZ
2UW0
2UW3
2UW4
2UW5
2UW6
2UW7
2UW8
2VNW
2VNY
2VO0
2VO3
2VO6
2VO7
3AMA
3AMB
3L9L
3L9M
3L9N
3MVJ
3NX8
3OOG
3OVV
3OWP
3OXT
3P0M
3POO
3VQH
3WYG
3X2U
3X2V
3X2W
4AXA
4IAC
4IAD
4IAF
4IAI
4IAK
4IAY
4IAZ
4IB0
4IB1
4IB3
4IE9
4IJ9
4O21
4O22
4UJ1
4UJ2
4UJ9
4UJA
4UJB
4WB5
4WB6
4WB7
4WB8
4Z83
4Z84
5BX6
5BX7
5DH9
5LCP
5LCQ
5LCR
5LCT
5LCU
5M0B
5M0C
5M0L
5M0U
5M6V
5M6Y
5M71
5M75
5N23
5XOJ
6E21
6E99
6E9L
6FRX
6QJ7
6X2U
6X2V
6X2W
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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