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PKIA and CASP6
Data Source:
BioGRID
(two hybrid)
PKIA
CASP6
Description
cAMP-dependent protein kinase inhibitor alpha
caspase 6
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
CAMP-dependent Protein Kinase Inhibitor Activity
Protein Binding
Protein Kinase A Catalytic Subunit Binding
Cysteine-type Endopeptidase Activity
Protein Binding
Cysteine-type Peptidase Activity
Identical Protein Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of CAMP-dependent Protein Kinase Activity
Proteolysis
Apoptotic Process
Epithelial Cell Differentiation
Regulation Of Apoptotic Process
Cellular Response To Staurosporine
Execution Phase Of Apoptosis
Pathways
Apoptotic cleavage of cellular proteins
Caspase-mediated cleavage of cytoskeletal proteins
Breakdown of the nuclear lamina
TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
3,5-Diiodotyrosine
Hydroxyfasudil
(2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine
(1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE
(1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE
(4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE
N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
(S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE
(2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
(2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
H-89
5-(2-methylpiperazine-1-sulfonyl)isoquinoline
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
3-pyridin-4-yl-1H-indazole
5-benzyl-1,3-thiazol-2-amine
1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium
Fasudil
Myristic acid
A-674563
3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE
Y-27632
Diseases
GWAS
Femoral neck bone mineral density (
22504420
)
Intraocular pressure (
29617998
31959993
)
Multiple sclerosis (
21833088
)
Optic disc size (
31809533
)
Systemic lupus erythematosus (
28714469
)
Systolic blood pressure response to hydrochlorothiazide in hypertension (
27802415
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Interacting Genes
12 interacting genes:
AGFG1
CASP6
DYNLL1
DYNLL2
EGFR
JUNB
MRNIP
PRC1
PRKACA
PRKACB
PRKX
XPO1
42 interacting genes:
APP
CASP10
CASP3
CASP8
CFLAR
CHD3
COPS6
DSP
EIF2S1
HTT
IKBKG
KRT18
LMNA
LMNB1
LNX1
MAPK6
MAPT
NEDD4
NTAQ1
NUAK1
PCYT1A
PIN1
PKIA
PPL
PRKAB2
PRKCZ
PSEN1
PSEN2
PSME3
RB1
SATB1
SP1
SRF
SRP72
STUB1
TAB1
TFAP2A
TOP1
TRAF1
UBE4A
UBE4B
VIM
Entrez ID
5569
839
HPRD ID
05828
03321
Ensembl ID
ENSG00000171033
ENSG00000138794
Uniprot IDs
A0A024R7Y9
P61925
P55212
PDB IDs
1CMK
1JLU
1Q8T
1VEB
1XH4
1XH5
1XH6
1XH7
1XH8
1XH9
1XHA
1YDR
2C1A
2C1B
2F7E
2GNI
2JDS
2JDT
2JDV
2L1L
2UVX
2UVY
2UVZ
2UW0
2UW3
2UW4
2UW5
2UW6
2UW7
2UW8
2VNW
2VNY
2VO0
2VO3
2VO6
2VO7
3AMA
3AMB
3L9L
3L9M
3L9N
3MVJ
3NX8
3OOG
3OVV
3OWP
3OXT
3P0M
3POO
3VQH
3WYG
3X2U
3X2V
3X2W
4AXA
4IAC
4IAD
4IAF
4IAI
4IAK
4IAY
4IAZ
4IB0
4IB1
4IB3
4IE9
4IJ9
4O21
4O22
4UJ1
4UJ2
4UJ9
4UJA
4UJB
4WB5
4WB6
4WB7
4WB8
4Z83
4Z84
5BX6
5BX7
5DH9
5LCP
5LCQ
5LCR
5LCT
5LCU
5M0B
5M0C
5M0L
5M0U
5M6V
5M6Y
5M71
5M75
5N23
5XOJ
6E21
6E99
6E9L
6FRX
6QJ7
6X2U
6X2V
6X2W
1MI9
2WDP
3K7E
3NKF
3NR2
3OD5
3P45
3P4U
3QNW
3S70
3S8E
3V6L
3V6M
4EJF
4FXO
4HVA
4IYR
4N5D
4N6G
4N7J
4N7M
4NBK
4NBL
4NBN
6DEU
6DEV
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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