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HDAC3 and BRMS1
Data Source:
BioGRID
(pull down)
HDAC3
BRMS1
Description
histone deacetylase 3
BRMS1 transcriptional repressor and anoikis regulator
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Transcription Repressor Complex
Mitotic Spindle
Nucleus
Nucleoplasm
Cytoplasm
Sin3-type Complex
Molecular Function
RNA Polymerase II Transcription Corepressor Binding
Chromatin Binding
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Cyclin Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Histone Deacetylase Binding
NF-kappaB Binding
Protein Binding
Histone Deacetylase Binding
NF-kappaB Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Protein Phosphorylation
Chromatin Organization
Protein Deacetylation
Circadian Rhythm
Negative Regulation Of Myotube Differentiation
Regulation Of Lipid Metabolic Process
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Positive Regulation Of TOR Signaling
Circadian Regulation Of Gene Expression
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Spindle Assembly
Histone H3 Deacetylation
Histone H4 Deacetylation
Cellular Response To Fluid Shear Stress
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Histone Deacetylation
Negative Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Protein Deacetylation
Positive Regulation Of Anoikis
Pathways
NR1D1 (REV-ERBA) represses gene expression
p75NTR negatively regulates cell cycle via SC1
PPARA activates gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Association of TriC/CCT with target proteins during biosynthesis
Regulation of lipid metabolism by PPARalpha
Circadian Clock
Circadian Clock
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
HDACs deacetylate histones
Potential therapeutics for SARS
Drugs
Vorinostat
Belinostat
Pracinostat
Panobinostat
Mocetinostat
Diseases
GWAS
Refractive error (
32231278
)
Bipolar disorder (
21926972
31043756
)
Interacting Genes
102 interacting genes:
ANKRD11
ANKRD12
AR
ARID4A
ATF3
BCL3
BCOR
BRINP1
BRIP1
BRMS1
CBFA2T3
CCN5
CCND1
CCT5
CEBPD
CORO2A
CREB3
CREBBP
CSNK2A1
CTBP1
DAXX
DHX30
EED
ELL
EP300
ESR1
EWSR1
GATA1
GATA2
GATA3
GCM1
GPS2
GTF2I
GTF2IRD1
H2AC1
H2BC1
H3C1
H4C1
HDAC1
HDAC10
HDAC4
HDAC5
HDAC7
HDAC9
HIF1A
HIF1AN
HNF4A
HR
HSPA4
HSPA8
IL16
JUN
KLF6
LCOR
MAPK11
MAPK14
MBD1
NACC1
NCOR1
NCOR2
NFKBIA
NR0B2
NR2C1
NR2E3
NRIP1
PARP1
PHB2
PIAS2
PML
PPARD
PPARG
PPP4C
PPP4R1
PRKDC
RARA
RB1
RBBP4
RELA
RUNX1T1
RUNX2
RXRA
SMYD1
SRC
SRY
STAT3
SUV39H1
SYK
TAB2
TBL1X
TBL1XR1
THAP11
THAP7
THRA
THRB
TMPO
TNFRSF14
TP53
TXNIP
VHL
XPO1
YY1
ZBTB16
49 interacting genes:
ANGPTL4
APP
ARID4A
BEX2
BRMS1L
CEP70
CSNK2A1
CYTOR
DIRAS3
DNAJB1
DNAJB6
E2F1
EEF1A1
EP300
GOLGB1
HDAC1
HDAC2
HDAC3
HDAC4
HDAC5
HDAC6
HSP90AA1
HSPA4
IL13RA2
ING1
KLK9
KPNA5
LRIF1
LYPD3
MCRS1
MRC2
NMI
PFDN5
PSMC3IP
RBBP4
RBBP7
RBP1
RELA
SAP30
SIN3A
SMARCE1
SMTN
SNAI1
SNX6
SPOP
SUDS3
TAF1
THRSP
UBE2D1
Entrez ID
8841
25855
HPRD ID
08950
05879
Ensembl ID
ENSG00000171720
ENSG00000174744
Uniprot IDs
O15379
G5E9I4
Q9HCU9
PDB IDs
4A69
2XUS
4AUV
Enriched GO Terms of Interacting Partners
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