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ACTN2 and PSMA1
Data Source:
BioGRID
(two hybrid)
ACTN2
PSMA1
Description
actinin alpha 2
proteasome 20S subunit alpha 1
Image
GO Annotations
Cellular Component
Extracellular Region
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Focal Adhesion
Z Disc
Filopodium
Cortical Actin Cytoskeleton
Platelet Alpha Granule Lumen
Pseudopodium
Dendritic Spine
Extracellular Exosome
Postsynaptic Density Membrane
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Proteasome Core Complex
Polysome
Proteasome Core Complex, Alpha-subunit Complex
Extracellular Exosome
Molecular Function
Integrin Binding
Calcium Ion Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Cytoskeletal Protein Binding
Structural Constituent Of Muscle
Protein Domain Specific Binding
LIM Domain Binding
Nuclear Receptor Coactivator Activity
Titin Binding
Identical Protein Binding
Ion Channel Binding
Actin Filament Binding
FATZ Binding
Titin Z Domain Binding
Lipopolysaccharide Binding
RNA Binding
Endopeptidase Activity
Protein Binding
Biological Process
MAPK Cascade
Platelet Degranulation
Cell Adhesion
Microspike Assembly
Muscle Filament Sliding
Regulation Of Membrane Potential
Regulation Of Apoptotic Process
Negative Regulation Of Potassium Ion Transport
Positive Regulation Of Potassium Ion Transport
Sarcomere Organization
Positive Regulation Of Transcription, DNA-templated
Focal Adhesion Assembly
Actin Filament Uncapping
Cardiac Muscle Cell Development
Protein Localization To Plasma Membrane
Phospholipase C-activating Angiotensin-activated Signaling Pathway
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Positive Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Protein Localization To Cell Surface
Regulation Of NMDA Receptor Activity
Positive Regulation Of Endocytic Recycling
Positive Regulation Of Cation Channel Activity
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of Cellular Amino Acid Metabolic Process
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Platelet degranulation
Nephrin family interactions
Striated Muscle Contraction
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS
Metabolite levels (
23823483
)
Periodontitis (CDC/AAP) (
24024966
)
Alzheimer's disease (cognitive decline) (
23535033
)
Bipolar disorder (
31043756
)
Diastolic blood pressure (
27841878
)
HDL cholesterol levels (
32203549
)
High chromosomal aberration frequency (total) (
31586183
)
Systolic blood pressure (
27841878
)
Triglyceride levels (
32203549
32154731
)
Vitamin D levels (
25208829
)
Interacting Genes
104 interacting genes:
ACTN1
ACTN3
ADAM12
ADORA2A
AKTIP
ANG
ANGPTL7
ASH2L
ATP5MC1
ATXN2
ATXN7
BAD
BRMS1L
CAMK2A
CAMK2D
CAMK2G
CAPN1
CCDC187
CD27
CLEC4D
CNNM3
COIL
CRABP2
CRADD
DISC1
DLG1
DLG4
DUX1
DYNLT2B
EPS8L1
ERBIN
FAM50B
FBXL22
GATA3
GOLGA7
GRIN1
GRIN2B
GSTT1
H4C9
HSPB1
HTR1B
ITGB3BP
KAT2B
KATNAL2
KCNA4
KCNA5
KCNN2
LDB3
LRP12
LRRC7
MAST2
MED14
MICALL2
MOS
MRPL10
MYBPC2
MYOT
MYOZ1
MYOZ2
MYOZ3
MYPN
NCAPH2
NCOA2
NCOR1
NKAPD1
NOS3
NR1I2
NRIP1
NTAQ1
ODF3B
PALLD
PDLIM1
PDLIM3
PKD2
PPP1CB
PPP1R9B
PSMA1
QARS1
RACK1
RAVER1
RPL35
RPP14
RTP5
SAXO1
SELE
SNAI1
SNAPIN
SNW1
SP100
SPA17
SRP9
SSX2IP
ST7
SYNPO2
SYNPO2L
TNN
TOLLIP
TTN
TULP3
USP2
UTRN
ZC2HC1C
ZNF446
ZNRD2
169 interacting genes:
ABCD3
ABI2
ABI3
ACTN1
ACTN2
AGR2
APIP
APP
BANF2
BLZF1
C11orf49
C22orf39
CABP5
CALCOCO2
CBS
CCDC102B
CCDC136
CCDC153
CCDC85B
CCNH
CDA
CDKN2D
CDR2
CEP70
CEP72
CFAP206
CHMP1A
CINP
COG4
COG6
COIL
CRX
DCTD
DCTPP1
DDIT4L
DEF6
DLEU1
DYDC1
DYNLT1
EHMT2
EIF4A3
EMSY
ERBB2
FNDC11
GNPTAB
GOLGA2
GOLGA6A
GPHN
GSDMD
GUCD1
HEXIM2
HOMER3
HOMEZ
HOOK2
HOXC11
HSD17B14
HSF2BP
IFT20
IKZF1
IKZF3
INO80E
IPO13
KAZN
KCTD1
KCTD13
KCTD17
KCTD6
KCTD7
KCTD9
KHDRBS3
KRT13
KRT15
KRT19
KRT31
KRT34
KRT37
KRT38
KRT40
KRTAP1-1
KRTAP1-3
KRTAP4-1
KRTAP5-9
KRTAP6-3
LDB1
LDOC1
LMO2
LONRF1
LZTFL1
LZTS1
LZTS2
MAD1L1
MAPK1
MAPRE1
MAPRE3
MCM6
MID2
MIEF1
MKNK2
MKRN3
MLH1
MRFAP1L1
MSANTD4
MT-CO2
MTUS2
NAB2
NBPF19
NECAB2
NME7
NMI
NOP53
NOTCH2NLA
PCBD1
PCYT2
PICK1
PLK1
PM20D2
PNMA1
PNMA2
PNMA5
POLR1C
POMP
PPCDC
PRDM14
PRIMPOL
PRKN
PRPH
PSMA2
PSMA3
PSMA4
PSMA7
PSMB1
PSMB10
PSMB2
PSMB5
RAD54B
RBCK1
REL
RFC2
RGS19
ROPN1
SAT1
SFMBT1
SH3BP4
SH3GLB1
SLF2
SPDEF
SSX2IP
TCF12
TCF4
TDO2
TEKT4
TNFAIP1
TNR
TRAF1
TRAF5
TRIM10
TRIM23
TRIM27
TRIM42
TRIM54
TSC22D4
UBXN11
VCP
VIM
VMAC
WTAP
YPEL5
ZFAND1
ZMYND19
Entrez ID
88
5682
HPRD ID
00019
04170
Ensembl ID
ENSG00000077522
ENSG00000129084
Uniprot IDs
F6THM6
P35609
Q59FD9
B4E0X6
P25786
PDB IDs
1H8B
1HCI
1QUU
4D1E
5A36
5A37
5A38
5A4B
6SWT
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
Enriched GO Terms of Interacting Partners
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