ACTN2 and KCNN2

Data Source:
BioGRID (pull down)

		ACTN2	KCNN2
Description		actinin alpha 2	potassium calcium-activated channel subfamily N member 2
Image
GO Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Z Disc Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Dendritic Spine Extracellular Exosome Postsynaptic Density Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane Z Disc Neuron Projection Neuronal Cell Body Dendritic Spine
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Protein Domain Specific Binding LIM Domain Binding Nuclear Receptor Coactivator Activity Titin Binding Identical Protein Binding Ion Channel Binding Actin Filament Binding FATZ Binding Titin Z Domain Binding	Protein Binding Calmodulin Binding Calcium-activated Potassium Channel Activity Small Conductance Calcium-activated Potassium Channel Activity Protein Domain Specific Binding Protein Homodimerization Activity Alpha-actinin Binding
	Biological Process	MAPK Cascade Platelet Degranulation Cell Adhesion Microspike Assembly Muscle Filament Sliding Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Sarcomere Organization Positive Regulation Of Transcription, DNA-templated Focal Adhesion Assembly Actin Filament Uncapping Cardiac Muscle Cell Development Protein Localization To Plasma Membrane Phospholipase C-activating Angiotensin-activated Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Protein Localization To Cell Surface Regulation Of NMDA Receptor Activity Positive Regulation Of Endocytic Recycling Positive Regulation Of Cation Channel Activity	Ion Transport Potassium Ion Transport Potassium Ion Transmembrane Transport Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport
Pathways		Platelet degranulation Nephrin family interactions Striated Muscle Contraction Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Ca2+ activated K+ channels
Drugs			Procaine Miconazole Trimebutine
Diseases
GWAS		Metabolite levels ( 23823483) Periodontitis (CDC/AAP) ( 24024966)	Alzheimer disease and age of onset ( 26830138) Atrial fibrillation ( 28416818 30061737 29892015) Coronary arterial lesions in patients with Kawasaki disease ( 23677057) Diastolic blood pressure ( 27841878) Generalized epilepsy ( 30531953) JT interval (sulfonylurea treatment interaction) ( 27958378) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Systolic blood pressure ( 27841878)
Interacting Genes		104 interacting genes: ACTN1 ACTN3 ADAM12 ADORA2A AKTIP ANG ANGPTL7 ASH2L ATP5MC1 ATXN2 ATXN7 BAD BRMS1L CAMK2A CAMK2D CAMK2G CAPN1 CCDC187 CD27 CLEC4D CNNM3 COIL CRABP2 CRADD DISC1 DLG1 DLG4 DUX1 DYNLT2B EPS8L1 ERBIN FAM50B FBXL22 GATA3 GOLGA7 GRIN1 GRIN2B GSTT1 H4C9 HSPB1 HTR1B ITGB3BP KAT2B KATNAL2 KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MAST2 MED14 MICALL2 MOS MRPL10 MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 MYPN NCAPH2 NCOA2 NCOR1 NKAPD1 NOS3 NR1I2 NRIP1 NTAQ1 ODF3B PALLD PDLIM1 PDLIM3 PKD2 PPP1CB PPP1R9B PSMA1 QARS1 RACK1 RAVER1 RPL35 RPP14 RTP5 SAXO1 SELE SNAI1 SNAPIN SNW1 SP100 SPA17 SRP9 SSX2IP ST7 SYNPO2 SYNPO2L TNN TOLLIP TTN TULP3 USP2 UTRN ZC2HC1C ZNF446 ZNRD2	4 interacting genes: ACTN2 CALM1 SRPK1 SRPK2
Entrez ID		88	3781
HPRD ID		00019	09323
Ensembl ID		ENSG00000077522	ENSG00000080709
Uniprot IDs		F6THM6 P35609 Q59FD9	A0A3F2YNY5 Q9H2S1
PDB IDs		1H8B 1HCI 1QUU 4D1E 5A36 5A37 5A38 5A4B 6SWT	5V02 5WBX 5WC5 6ALE
Enriched GO Terms of Interacting Partners?
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