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TNFRSF11A and TAB2
Data Source:
HPRD
(in vivo)
TNFRSF11A
TAB2
Description
TNF receptor superfamily member 11a
TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Image
GO Annotations
Cellular Component
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
Nucleoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Molecular Function
Transmembrane Signaling Receptor Activity
Tumor Necrosis Factor-activated Receptor Activity
Protein Binding
Cytokine Binding
Signaling Receptor Activity
Metal Ion Binding
Protein Binding
Ubiquitin Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Biological Process
Ossification
Adaptive Immune Response
Monocyte Chemotaxis
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Response To Radiation
Osteoclast Differentiation
Response To Lipopolysaccharide
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Cytokine
Response To Tumor Necrosis Factor
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Bone Resorption
Lymph Node Development
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Circadian Temperature Homeostasis
Mammary Gland Alveolus Development
Response To Interleukin-1
Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion
TNFSF11-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling
Multinuclear Osteoclast Differentiation
Activation Of MAPK Activity
Stimulatory C-type Lectin Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Heart Development
Negative Regulation Of Autophagy
Response To Lipopolysaccharide
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Protein Kinase Activity
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Pathways
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Nuclear signaling by ERBB4
Nuclear signaling by ERBB4
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
ENMD-1198
Diseases
Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
32296059
)
Asthma (age of onset) (
31036433
)
Asthma (childhood onset) (
31036433
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Blood protein levels (
30072576
29875488
)
Bone mineral density (paediatric, skull) (
24945404
)
Bone mineral density (spine) (
19801982
)
Femoral neck bone mineral density (
29499414
)
Heel bone mineral density (
30598549
28869591
)
Lumbar spine bone mineral density (
29499414
22504420
)
Myasthenia gravis (
25643325
)
Paget's disease (
21623375
20436471
)
Response to antipsychotic treatment (
23241943
)
Serum albumin level (
23022100
)
Serum alkaline phosphatase levels (
29403010
)
Vitiligo (
27723757
)
Breast cancer (
22383897
29059683
)
Coronary artery disease (
33020668
)
Diverticulitis (
28585551
)
Dupuytren's disease (
28886342
21732829
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Interacting Genes
13 interacting genes:
CBL
CBLB
FHL2
GAB2
MAP3K7
SRC
TAB2
TNFSF11
TRAF1
TRAF2
TRAF3
TRAF5
TRAF6
43 interacting genes:
APP
CAMK2A
CST9L
EIF2AK2
EMILIN1
ERBB4
FN1
FOSL1
GTF2I
HDAC1
HDAC3
HDAC5
HSF2BP
IKBKB
IKBKG
IRAK1
KRT85
MAP3K7
NCOR1
NFKB1
NR2C2
NUMBL
PPIL3
PPP2CB
SLC19A3
TAB1
TBL1X
TGM2
TNFRSF11A
TPM3
TRAF2
TRAF3IP1
TRAF6
TTN
UBC
UBE2I
VIM
VPS52
XIAP
YWHAZ
ZBTB16
ZFP64
ZNF143
Entrez ID
8792
23118
HPRD ID
04609
05483
Ensembl ID
ENSG00000141655
ENSG00000055208
Uniprot IDs
Q9Y6Q6
B4DIR9
Q9NYJ8
PDB IDs
1LB5
2DAE
2WWZ
2WX0
2WX1
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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