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TAB2
Description
TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Molecular Function
Protein Binding
Ubiquitin Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Biological Process
Activation Of MAPK Activity
Stimulatory C-type Lectin Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Heart Development
Negative Regulation Of Autophagy
Response To Lipopolysaccharide
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Protein Kinase Activity
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Pathways
Nuclear signaling by ERBB4
Nuclear signaling by ERBB4
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS
Breast cancer (
22383897
29059683
)
Coronary artery disease (
33020668
)
Diverticulitis (
28585551
)
Dupuytren's disease (
28886342
21732829
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Interacting Genes
43 interacting genes:
APP
CAMK2A
CST9L
EIF2AK2
EMILIN1
ERBB4
FN1
FOSL1
GTF2I
HDAC1
HDAC3
HDAC5
HSF2BP
IKBKB
IKBKG
IRAK1
KRT85
MAP3K7
NCOR1
NFKB1
NR2C2
NUMBL
PPIL3
PPP2CB
SLC19A3
TAB1
TBL1X
TGM2
TNFRSF11A
TPM3
TRAF2
TRAF3IP1
TRAF6
TTN
UBC
UBE2I
VIM
VPS52
XIAP
YWHAZ
ZBTB16
ZFP64
ZNF143
Entrez ID
23118
HPRD ID
05483
Ensembl ID
ENSG00000055208
Uniprot IDs
B4DIR9
Q9NYJ8
PDB IDs
2DAE
2WWZ
2WX0
2WX1
Enriched GO Terms of Interacting Partners
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