EIF3H and EIF3K

Data Source:
HPRD (in vitro)

		EIF3H	EIF3K
Description		eukaryotic translation initiation factor 3 subunit H	eukaryotic translation initiation factor 3 subunit K
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Polysomal Ribosome Extracellular Exosome	Nucleus Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Metallopeptidase Activity Isopeptidase Activity Ubiquitinyl Hydrolase Activity	Translation Initiation Factor Activity Protein Binding Ribosome Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation Proteolysis Protein Phosphopantetheinylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Asthma ( 29273806) Body mass index ( 25673413) Colorectal cancer ( 26965516 25990418 18372905 30529582 21761138 26151821 29471430 24737748) Colorectal cancer or advanced adenoma ( 30510241) Corneal curvature ( 22969067) Height ( 31562340) Metabolite levels ( 23823483) Morning person ( 30696823) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Right lateral prefrontal cortical growth ( 29682794) Systemic juvenile idiopathic arthritis ( 27927641) Waist circumference adjusted for body mass index ( 28552196)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: ABI1 ABI2 ABI3 CCDC85B DISC1 EIF3G EIF3K NCK2 SORBS2 SORBS3 SPTBN1	7 interacting genes: CCND3 EIF3C EIF3G EIF3H EIF3J EIF3L SPP1
Entrez ID		8667	27335
HPRD ID		04885	11740
Ensembl ID		ENSG00000147677	ENSG00000178982
Uniprot IDs		O15372 Q6IB98	K7EK53 K7ERF1 Q9UBQ5 U3LUI4
PDB IDs		3J8B 3J8C 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09	1RZ4 3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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