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SSNA1 and SPAST
Data Source:
HPRD
(two hybrid, in vivo)
SSNA1
SPAST
Description
SS nuclear autoantigen 1
spastin
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Centrosome
Cytosol
Ciliary Basal Body
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Lipid Droplet
Centrosome
Spindle
Cytosol
Microtubule
Microtubule Cytoskeleton
Integral Component Of Membrane
Midbody
Cytoplasmic Vesicle
Nuclear Membrane
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Axon Cytoplasm
Molecular Function
Protein Binding
Identical Protein Binding
Protein Binding
ATP Binding
Microtubule Binding
Microtubule-severing ATPase Activity
Isomerase Activity
ATPase Activity
Alpha-tubulin Binding
Protein-containing Complex Binding
Beta-tubulin Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Intraciliary Transport
Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway
Ciliary Basal Body-plasma Membrane Docking
Mitotic Cytokinesis
Microtubule Bundle Formation
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Axonogenesis
Anterograde Axonal Transport
Metabolic Process
Exit From Mitosis
Axonal Transport Of Mitochondrion
Positive Regulation Of Microtubule Depolymerization
Cytoplasmic Microtubule Organization
Nuclear Envelope Reassembly
Positive Regulation Of Cytokinesis
Cytokinetic Process
Protein Hexamerization
Microtubule Severing
Mitotic Spindle Disassembly
Protein Homooligomerization
Cytoskeleton-dependent Cytokinesis
Membrane Fission
Pathways
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases
Hereditary spastic paraplegia (SPG)
GWAS
Apolipoprotein A1 levels (
32203549
)
Bisphosphonate-associated atypical femoral fracture (
31006051
)
Inflammatory biomarkers (
24182552
)
Interleukin-18 levels (
31584380
)
Male-pattern baldness (
28196072
)
Interacting Genes
12 interacting genes:
CDC37
EHHADH
LNX1
NTAQ1
PICK1
PSMC5
RNF4
SDCBP
SPAST
TBC1D7
TCEANC
TXN2
4 interacting genes:
CHMP1B
IST1
RTN1
SSNA1
Entrez ID
8636
6683
HPRD ID
10251
05044
Ensembl ID
ENSG00000176101
ENSG00000021574
Uniprot IDs
A0A024R8G6
O43805
E5KRP5
E5KRP6
Q9UBP0
PDB IDs
3EAB
3VFD
5Z6Q
5Z6R
6PEK
6PEN
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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