NPFF and NPFFR2

Data Source:
HPRD (in vivo)

		NPFF	NPFFR2
Description		neuropeptide FF-amide peptide precursor	neuropeptide FF receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Dendrite Vesicle Perikaryon Axon Terminus Postsynapse	Plasma Membrane Integral Component Of Plasma Membrane Actin Cytoskeleton
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Neuropeptide Hormone Activity	G Protein-coupled Receptor Activity Neuropeptide Receptor Activity Opioid Receptor Binding Peptide Binding
	Biological Process	Acute Inflammatory Response To Antigenic Stimulus Regulation Of Membrane Depolarization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Chemical Synaptic Transmission Negative Regulation Of Heart Rate Spinal Cord Development Vasopressin Secretion Negative Regulation Of Appetite Response To Drug Response To Morphine Positive Regulation Of Blood Pressure Negative Regulation Of Insulin Secretion Regulation Of Sensory Perception Of Pain Excitatory Postsynaptic Potential Maternal Process Involved In Female Pregnancy Somatostatin Secretion	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Detection Of Abiotic Stimulus Regulation Of MAPK Cascade Regulation Of Adenylate Cyclase Activity Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: NPFFR1 NPFFR2 NPY ZDHHC17	6 interacting genes: FKBP7 HCRT NPFF NPY TMEM218 TRARG1
Entrez ID		8620	10886
HPRD ID		06869	16244
Ensembl ID		ENSG00000139574	ENSG00000056291
Uniprot IDs		O15130	A0PJM9 Q9Y5X5
PDB IDs
Enriched GO Terms of Interacting Partners?
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