PIAS1 and FLI1

Data Source:
BioGRID (enzymatic study)

		PIAS1	FLI1
Description		protein inhibitor of activated STAT 1	Fli-1 proto-oncogene, ETS transcription factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm PML Body Nuclear Speck	Chromatin Nucleus Nucleoplasm Cytosol Nuclear Body
	Molecular Function	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding SUMO Transferase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding SUMO Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Receptor Signaling Pathway Via JAK-STAT Spermatogenesis Visual Learning Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Smooth Muscle Cell Differentiation Regulation Of Interferon-gamma-mediated Signaling Pathway Protein-DNA Complex Assembly	Regulation Of Transcription By RNA Polymerase II Hemostasis Blood Circulation Animal Organ Morphogenesis Cell Differentiation Megakaryocyte Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins Formation of Incision Complex in GG-NER Regulation of IFNG signaling	Transcriptional regulation of granulopoiesis
Drugs
Diseases			Ewing's sarcoma
GWAS		Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Major depressive disorder ( 23377640) Number of twin births ( 30760885)	Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Corneal astigmatism ( 30306274) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549) Height ( 20881960 31562340) Left ventricular obstructive tract defect (inherited effect) ( 28468790) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Myopia (pathological) ( 23049088) Non-albumin protein levels ( 29403010) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Refractive error ( 32231278) Rheumatoid arthritis ( 22446963) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 26502338) Vitiligo ( 27723757)
Interacting Genes		107 interacting genes: AKT1 AR ATXN1 AXIN1 BARD1 BRCA1 CASP8 CBS CDK4 CEBPA CEBPE CHUK CNOT7 CREB1 CREBBP CSNK2A1 CSRP2 DCLRE1A DDX21 DDX5 DNM1 DNMT3A ELK3 EP300 ESR1 ESR2 FANCI FHL3 FLI1 GATA4 GLUL GRM8 GSK3B GTF2IRD1 HECTD2 HIC1 HTT IKZF5 JUN KLF3 L3MBTL2 LSM3 MAML1 MBD1 MDC1 MDM2 MITF MSX1 MX1 MYB NCOR1 NFATC1 NIN NR2F2 NR3C2 NR5A1 PAXIP1 PGR PIAS2 PIAS4 PLAG1 PML PPP1CA PPP1CC PRDM1 PRPF40A PSME3 PTK2 PTPN1 QKI RAD54L2 RBBP6 RELA SATB1 SATB2 SERBP1 SGTA SKIL SMAD1 SMAD4 SMAD7 SNAI2 SNIP1 SP3 SPOP SREBF2 STAT1 SUFU SUMO1 SUMO1P1 SUMO2 SUMO3 TBP TERF2 TEX11 TP53 TP73 TRIM27 TRIM5 TRIM55 TRIM63 TSG101 UBE2I UBE2L3 YWHAZ ZNF451 ZNF76	18 interacting genes: BRCA1 CTBP2 ELK1 ERG ETV6 EWSR1 GATA1 KLF1 PIAS1 PIAS2 PRKCD SIAH1 SMAD3 SMAD9 SOX30 SRF TDP2 UBE2I
Entrez ID		8554	2313
HPRD ID		16029	01901
Ensembl ID		ENSG00000033800	ENSG00000151702
Uniprot IDs		O75925 Q1XBU8	A0A024R3K4 A0A024R3M5 A0A024R3N6 Q01543
PDB IDs		1V66	1FLI 1X66 2YTU 5E8G 5E8I 5JVT
Enriched GO Terms of Interacting Partners?
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