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PIAS1 and HECTD2
Data Source:
BioGRID
(enzymatic study, affinity chromatography technology, unspecified method)
PIAS1
HECTD2
Description
protein inhibitor of activated STAT 1
HECT domain E3 ubiquitin protein ligase 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
PML Body
Nuclear Speck
Cytosol
Molecular Function
RNA Polymerase II Transcription Factor Binding
DNA Binding
Transcription Coregulator Activity
Transcription Corepressor Activity
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
SUMO Transferase Activity
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
SUMO Ligase Activity
Ubiquitin-protein Transferase Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Receptor Signaling Pathway Via JAK-STAT
Spermatogenesis
Visual Learning
Protein Sumoylation
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Sumoylation
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Fat Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Smooth Muscle Cell Differentiation
Regulation Of Interferon-gamma-mediated Signaling Pathway
Protein-DNA Complex Assembly
Protein Polyubiquitination
Pathways
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
Formation of Incision Complex in GG-NER
Regulation of IFNG signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Diastolic blood pressure (
30224653
)
Diverticular disease (
30177863
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Major depressive disorder (
23377640
)
Number of twin births (
30760885
)
Idiopathic pulmonary fibrosis (
31710517
)
Interacting Genes
107 interacting genes:
AKT1
AR
ATXN1
AXIN1
BARD1
BRCA1
CASP8
CBS
CDK4
CEBPA
CEBPE
CHUK
CNOT7
CREB1
CREBBP
CSNK2A1
CSRP2
DCLRE1A
DDX21
DDX5
DNM1
DNMT3A
ELK3
EP300
ESR1
ESR2
FANCI
FHL3
FLI1
GATA4
GLUL
GRM8
GSK3B
GTF2IRD1
HECTD2
HIC1
HTT
IKZF5
JUN
KLF3
L3MBTL2
LSM3
MAML1
MBD1
MDC1
MDM2
MITF
MSX1
MX1
MYB
NCOR1
NFATC1
NIN
NR2F2
NR3C2
NR5A1
PAXIP1
PGR
PIAS2
PIAS4
PLAG1
PML
PPP1CA
PPP1CC
PRDM1
PRPF40A
PSME3
PTK2
PTPN1
QKI
RAD54L2
RBBP6
RELA
SATB1
SATB2
SERBP1
SGTA
SKIL
SMAD1
SMAD4
SMAD7
SNAI2
SNIP1
SP3
SPOP
SREBF2
STAT1
SUFU
SUMO1
SUMO1P1
SUMO2
SUMO3
TBP
TERF2
TEX11
TP53
TP73
TRIM27
TRIM5
TRIM55
TRIM63
TSG101
UBE2I
UBE2L3
YWHAZ
ZNF451
ZNF76
2 interacting genes:
PIAS1
UBE2L3
Entrez ID
8554
143279
HPRD ID
16029
13643
Ensembl ID
ENSG00000033800
ENSG00000165338
Uniprot IDs
O75925
Q1XBU8
B3KV18
B4DIQ2
Q5U5R9
X6R824
PDB IDs
1V66
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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