DGKD and DGKH

Data Source:
HPRD (in vivo)

		DGKD	DGKH
Description		diacylglycerol kinase delta	diacylglycerol kinase eta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit	Cytoplasm Endosome Plasma Membrane Actin Cytoskeleton Intracellular Membrane-bounded Organelle
	Molecular Function	NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding ATP Binding Kinase Binding Diacylglycerol Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	NAD+ Kinase Activity Diacylglycerol Kinase Activity ATP Binding Metal Ion Binding
	Biological Process	Phosphatidic Acid Biosynthetic Process Endocytosis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Response To Organic Substance Protein Transport Second-messenger-mediated Signaling Platelet Activation Intracellular Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Diacylglycerol Metabolic Process Lipid Phosphorylation Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Clathrin-dependent Endocytosis	Phosphatidic Acid Biosynthetic Process Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Lipid Phosphorylation
Pathways		Effects of PIP2 hydrolysis	Effects of PIP2 hydrolysis
Drugs		Phosphatidyl serine alpha-Tocopherol succinate	alpha-Tocopherol succinate
Diseases
GWAS		Bilirubin levels ( 20639394 32084209) Calcium levels ( 24068962 29403010 20705733) Crohn's disease ( 22412388) Glaucoma (primary open-angle) ( 29891935) Kidney stones ( 31729369) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Total body bone mineral density ( 29304378) Type 2 diabetes ( 32499647 30718926) Urinary calcium excretion ( 31993563)	Bipolar disorder ( 17486107) Blood urea nitrogen levels ( 29403010) Body size at age 10 ( 32376654) Calcium levels ( 24068962) Cortisol levels (saliva) ( 28843169) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate ( 29403010) Height ( 20189936) Kidney stones ( 31729369) Metabolite levels (X-11787) ( 23934736) Nephrolithiasis ( 22396660) Plasma anti-thyroglobulin levels ( 29678681) Pulmonary function in asthmatics ( 25221879) Systolic blood pressure ( 30224653) Urolithiasis ( 30975718)
Interacting Genes		8 interacting genes: DGKH DYSF HAX1 IGSF21 MYH2 PRKCA SREK1 TNFRSF14	2 interacting genes: DGKD TRAF5
Entrez ID		8527	160851
HPRD ID		03492	07237
Ensembl ID		ENSG00000077044	ENSG00000102780
Uniprot IDs		A0A024R495 Q16760	A8K0I1 B4DYW1 Q86XP1
PDB IDs		1R79 3BQ7
Enriched GO Terms of Interacting Partners?
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