DGKD and SREK1

Data Source:
BioGRID (two hybrid)

		DGKD	SREK1
Description		diacylglycerol kinase delta	splicing regulatory glutamic acid and lysine rich protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit	Nucleoplasm Spliceosomal Complex Nuclear Speck
	Molecular Function	NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding ATP Binding Kinase Binding Diacylglycerol Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	RNA Binding Protein Binding
	Biological Process	Phosphatidic Acid Biosynthetic Process Endocytosis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Response To Organic Substance Protein Transport Second-messenger-mediated Signaling Platelet Activation Intracellular Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Diacylglycerol Metabolic Process Lipid Phosphorylation Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Clathrin-dependent Endocytosis	MRNA Processing RNA Splicing
Pathways		Effects of PIP2 hydrolysis
Drugs		Phosphatidyl serine alpha-Tocopherol succinate
Diseases
GWAS		Bilirubin levels ( 20639394 32084209) Calcium levels ( 24068962 29403010 20705733) Crohn's disease ( 22412388) Glaucoma (primary open-angle) ( 29891935) Kidney stones ( 31729369) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Total body bone mineral density ( 29304378) Type 2 diabetes ( 32499647 30718926) Urinary calcium excretion ( 31993563)	Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure ( 30224653)
Interacting Genes		8 interacting genes: DGKH DYSF HAX1 IGSF21 MYH2 PRKCA SREK1 TNFRSF14	60 interacting genes: ARL6IP4 CD8A CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GPRASP2 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 NCL NPM1 PABPC1 PABPC4 PARP1 PIN1 PRPF40A RACK1 RBM10 RBM39 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B TXLNA YBX1 ZRANB2
Entrez ID		8527	140890
HPRD ID		03492	18043
Ensembl ID		ENSG00000077044	ENSG00000153914
Uniprot IDs		A0A024R495 Q16760	Q8WXA9
PDB IDs		1R79 3BQ7
Enriched GO Terms of Interacting Partners?
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