LINGO1 and RTN4R

Data Source:
HPRD (in vitro, in vivo)

		LINGO1	RTN4R
Description		leucine rich repeat and Ig domain containing 1	reticulon 4 receptor
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Membrane Extracellular Matrix	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Anchored Component Of External Side Of Plasma Membrane Neuron Projection Neuronal Cell Body Dendritic Shaft Perikaryon Axonal Growth Cone Membrane Raft Extracellular Exosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding	Protein Binding Heparin Binding Chondroitin Sulfate Binding Signaling Receptor Activity Neuregulin Receptor Activity Ganglioside GM1 Binding Ganglioside GT1b Binding
	Biological Process	Negative Regulation Of Axonogenesis	Cell Surface Receptor Signaling Pathway Negative Regulation Of Neuron Projection Development Corpus Callosum Development Neuronal Signal Transduction Negative Regulation Of Axon Extension Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Axon Regeneration Negative Regulation Of Axonogenesis
Pathways		Axonal growth inhibition (RHOA activation)	Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS		Adult body size ( 32376654) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Essential tremor ( 19182806) Feeling miserable ( 29500382) General factor of neuroticism ( 30867560) Hemoglobin A1c levels ( 29403010) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neuroticism ( 27089181) Risky sexual behaviors (alcohol dependence interaction) ( 28990359) Systemic lupus erythematosus ( 33536424)	Blood protein levels ( 30072576 29875488) Obesity-related traits ( 23251661)
Interacting Genes		17 interacting genes: EFEMP2 FBLN1 FBXW7 FRS3 GOLGA2 HSD3B7 KRTAP10-1 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP9-2 MACO1 NGFR NTM RTN4R SPAG5 TRIM27	9 interacting genes: HOXA1 LINGO1 MAG MGAT5B NGFR OMG OTX1 RTN4 RTN4IP1
Entrez ID		84894	65078
HPRD ID		14322	16123
Ensembl ID		ENSG00000169783	ENSG00000040608
Uniprot IDs		Q96FE5	Q9BZR6
PDB IDs		2ID5 4OQT	1OZN 1P8T
Enriched GO Terms of Interacting Partners?
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