RTN4R and RTN4

Data Source:
HPRD (in vivo)

		RTN4R	RTN4
Description		reticulon 4 receptor	reticulon 4
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GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Anchored Component Of External Side Of Plasma Membrane Neuron Projection Neuronal Cell Body Dendritic Shaft Perikaryon Axonal Growth Cone Membrane Raft Extracellular Exosome	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Integral Component Of Endoplasmic Reticulum Membrane Cell Projection Neuronal Cell Body Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Membrane
	Molecular Function	Protein Binding Heparin Binding Chondroitin Sulfate Binding Signaling Receptor Activity Neuregulin Receptor Activity Ganglioside GM1 Binding Ganglioside GT1b Binding	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Cadherin Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Negative Regulation Of Neuron Projection Development Corpus Callosum Development Neuronal Signal Transduction Negative Regulation Of Axon Extension Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Axon Regeneration Negative Regulation Of Axonogenesis	Blastocyst Formation Apoptotic Process Axonal Fasciculation Positive Regulation Of Epithelial Cell Migration Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Growth Negative Regulation Of Axon Extension Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Axonogenesis Protein Stabilization Nuclear Pore Complex Assembly Positive Regulation Of Protein Kinase B Signaling Cardiac Epithelial To Mesenchymal Transition Protein Localization To Lysosome Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Cellular Sphingolipid Homeostasis Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of ERBB3 Signaling Pathway Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Branching Morphogenesis Of A Nerve
Pathways		Axonal growth inhibition (RHOA activation)	Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Obesity-related traits ( 23251661)	Adult body size ( 32376654) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Obesity (extreme) ( 19553259) Platelet count ( 32888494) Systolic blood pressure ( 30224653)
Interacting Genes		9 interacting genes: HOXA1 LINGO1 MAG MGAT5B NGFR OMG OTX1 RTN4 RTN4IP1	47 interacting genes: BAIAP2 BCL2 BCL2L1 BDKRB1 CCR4 CERT1 CHRM4 CLN8 CNTNAP1 CRMP1 CYSLTR2 DRD2 ERBB2 ERBB3 ERBB4 F2RL1 FXR2 GLP1R GPR35 HLA-DPB1 HTR2C LAMA4 LINC01554 LMNA LRCH4 LRPAP1 MBP NAPA NR4A1 PLEKHF2 POT1 PRR13 RAB33A RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21
Entrez ID		65078	57142
HPRD ID		16123	07259
Ensembl ID		ENSG00000040608	ENSG00000115310
Uniprot IDs		Q9BZR6	Q9NQC3
PDB IDs		1OZN 1P8T	2G31 2JV5
Enriched GO Terms of Interacting Partners?
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