KMT5C and RBL2

Data Source:
HPRD (in vitro)

		KMT5C	RBL2
Description		lysine methyltransferase 5C	RB transcriptional corepressor like 2
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GO Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Heterochromatin Nucleus Nucleoplasm Pericentric Heterochromatin	Chromatin Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytosol Extracellular Exosome
	Molecular Function	Chromatin Binding Protein Binding Histone Binding Histone Methyltransferase Activity (H4-K20 Specific) Metal Ion Binding S-adenosyl-L-methionine Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding Protein Binding Promoter-specific Chromatin Binding
	Biological Process	DNA Repair Histone H4-K20 Trimethylation Positive Regulation Of Isotype Switching Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Chromatin Organization Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		PKMTs methylate histone lysines	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS			Body fat mass ( 28552196) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: H4C1 RB1 RBL1 RBL2	44 interacting genes: BRCA1 BRF1 BRF2 CCNA1 CCNA2 CCND1 CCND3 CCNE1 CDK2 CDK4 CDK6 CREG1 DCTN1 DGKZ E2F4 E2F5 EZH2 GRAMD4 HBP1 HDAC1 ID2 KMT5C LBX1 LDHC LIN52 MCM7 MNDA PCBD1 PHB PPP2CA RAF1 RBBP8 RBBP9 RINT1 SKP2 SMARCA4 SNW1 SUV39H1 TAF1 TOP1 TP53BP1 UBTF USP4 XBP1
Entrez ID		84787	5934
HPRD ID		15454	01576
Ensembl ID		ENSG00000133247	ENSG00000103479
Uniprot IDs		A0A0D9SF94 Q86Y97	Q08999
PDB IDs		3RQ4	4XI9 5C1D
Enriched GO Terms of Interacting Partners?
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