RBL2 and LDHC

Data Source:
BioGRID (two hybrid)

		RBL2	LDHC
Description		RB transcriptional corepressor like 2	lactate dehydrogenase C
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytosol Extracellular Exosome	Nucleus Cytosol Motile Cilium Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding Protein Binding Promoter-specific Chromatin Binding	L-lactate Dehydrogenase Activity
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Carbohydrate Metabolic Process Pyruvate Metabolic Process ATP Biosynthetic Process Lactate Biosynthetic Process From Pyruvate Lactate Oxidation Flagellated Sperm Motility
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry FOXO-mediated transcription of cell cycle genes	Pyruvate metabolism
Drugs			NADH
Diseases
GWAS		Body fat mass ( 28552196) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483)	Amyloid A serum levels ( 21124955) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 28240269)
Interacting Genes		44 interacting genes: BRCA1 BRF1 BRF2 CCNA1 CCNA2 CCND1 CCND3 CCNE1 CDK2 CDK4 CDK6 CREG1 DCTN1 DGKZ E2F4 E2F5 EZH2 GRAMD4 HBP1 HDAC1 ID2 KMT5C LBX1 LDHC LIN52 MCM7 MNDA PCBD1 PHB PPP2CA RAF1 RBBP8 RBBP9 RINT1 SKP2 SMARCA4 SNW1 SUV39H1 TAF1 TOP1 TP53BP1 UBTF USP4 XBP1	3 interacting genes: BRCA1 RBL2 SRPK2
Entrez ID		5934	3948
HPRD ID		01576	01027
Ensembl ID		ENSG00000103479	ENSG00000166796
Uniprot IDs		Q08999	A0A140VKA7 P07864
PDB IDs		4XI9 5C1D
Enriched GO Terms of Interacting Partners?
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