DOT1L and MLLT10

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		DOT1L	MLLT10
Description		DOT1 like histone lysine methyltransferase	MLLT10 histone lysine methyltransferase DOT1L cofactor
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Protein-containing Complex Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytosol Protein-containing Complex
	Molecular Function	DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K79 Specific) Histone Methyltransferase Activity	DNA Binding Chromatin Binding Protein Binding Nucleosome Binding Histone Binding Metal Ion Binding
	Biological Process	DNA Damage Checkpoint DNA Repair Chromatin Silencing At Telomere Positive Regulation Of Cell Population Proliferation Gene Expression Telomere Organization Histone H3-K79 Methylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Transcription Regulatory Region DNA Binding	Positive Regulation Of Transcription By RNA Polymerase II
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 23563607 18391950) Hematocrit ( 29403010) Hemoglobin ( 29403010) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 25673412) Hip minimal joint space width ( 27701424) Myocardial infarction ( 24916648) Osteoarthritis ( 22566624) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 26390057 27841878 29403010 27618448 30487518 30578418) Red blood cell count ( 29403010) Systolic blood pressure ( 27618448 30487518) White blood cell count ( 32888494)	Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 23535729) Epithelial ovarian cancer ( 25581431) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Gallstone disease ( 30504769) Hand grip strength ( 29691431) Lateral ventricular volume in normal aging ( 30258056) Meningioma ( 21804547) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) Multisite chronic pain ( 31194737) Oily fish consumption ( 32066663) Ovarian cancer ( 23535730) Pork consumption ( 32066663) Raw vegetable consumption ( 32066663) Subcutaneous adipose tissue ( 26480920) Urinary albumin-to-creatinine ratio ( 31630189) Urinary sodium excretion ( 31409800)
Interacting Genes		4 interacting genes: H3-4 MLLT10 MYCN STAT1	15 interacting genes: DISC1 DOT1L FOXI1 HNF1B HPCA MLLT1 NCALD NDEL1 POU2F1 POU6F2 RBPMS RGPD5 SS18 VEZF1 YEATS4
Entrez ID		84444	8028
HPRD ID		10455	03874
Ensembl ID		ENSG00000104885	ENSG00000078403
Uniprot IDs		Q8TEK3	P55197 Q59EQ6 Q6N002
PDB IDs		1NW3 2MV7 3QOW 3QOX 3SR4 3SX0 3UWP 4EK9 4EKG 4EKI 4EQZ 4ER0 4ER3 4ER5 4ER6 4ER7 4HRA 4WVL 5DRT 5DRY 5DSX 5DT2 5DTM 5DTQ 5DTR 5JUW 5MVS 5MW3 5MW4 6IN3 6J99 6JM9 6JMA 6JN2 6NJ9 6NN6 6NOG 6NQA 6O96 6TE6 6TEL 6TEN	5DAG 5DAH 6CKN 6CKO 6JN2
Enriched GO Terms of Interacting Partners?
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