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DOT1L
Description
DOT1 like histone lysine methyltransferase
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Molecular Function
DNA Binding
Protein Binding
Histone-lysine N-methyltransferase Activity
Histone Methyltransferase Activity (H3-K79 Specific)
Histone Methyltransferase Activity
Biological Process
DNA Damage Checkpoint
DNA Repair
Chromatin Silencing At Telomere
Positive Regulation Of Cell Population Proliferation
Gene Expression
Telomere Organization
Histone H3-K79 Methylation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Transcription Regulatory Region DNA Binding
Pathways
PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Heel bone mineral density (
30598549
28869591
)
Height (
28552196
20881960
25282103
23563607
18391950
)
Hematocrit (
29403010
)
Hemoglobin (
29403010
)
Hemoglobin levels (
32327693
)
Hip circumference adjusted for BMI (
25673412
)
Hip minimal joint space width (
27701424
)
Myocardial infarction (
24916648
)
Osteoarthritis (
22566624
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Pulse pressure (
26390057
27841878
29403010
27618448
30487518
30578418
)
Red blood cell count (
29403010
)
Systolic blood pressure (
27618448
30487518
)
White blood cell count (
32888494
)
Interacting Genes
4 interacting genes:
H3-4
MLLT10
MYCN
STAT1
Entrez ID
84444
HPRD ID
10455
Ensembl ID
ENSG00000104885
Uniprot IDs
Q8TEK3
PDB IDs
1NW3
2MV7
3QOW
3QOX
3SR4
3SX0
3UWP
4EK9
4EKG
4EKI
4EQZ
4ER0
4ER3
4ER5
4ER6
4ER7
4HRA
4WVL
5DRT
5DRY
5DSX
5DT2
5DTM
5DTQ
5DTR
5JUW
5MVS
5MW3
5MW4
6IN3
6J99
6JM9
6JMA
6JN2
6NJ9
6NN6
6NOG
6NQA
6O96
6TE6
6TEL
6TEN
Enriched GO Terms of Interacting Partners
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