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CASP10 and BFAR
Data Source:
HPRD
(in vivo, in vitro)
CASP10
BFAR
Description
caspase 10
bifunctional apoptosis regulator
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
CD95 Death-inducing Signaling Complex
Ripoptosome
Endoplasmic Reticulum
Integral Component Of Plasma Membrane
Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Molecular Function
Cysteine-type Endopeptidase Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Death Effector Domain Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Protein Binding
Protein-macromolecule Adaptor Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Caspase Binding
Biological Process
Proteolysis
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Negative Regulation Of IRE1-mediated Unfolded Protein Response
Pathways
TP53 Regulates Transcription of Caspase Activators and Caspases
FasL/ CD95L signaling
TRAIL signaling
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Drugs
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Basal cell carcinoma (
25855136
)
Chronic lymphocytic leukemia (
28165464
23770605
)
Chronic lymphocytic leukemia or rheumatoid arthritis (
31407831
)
Mean corpuscular hemoglobin (
32888494
)
Interacting Genes
30 interacting genes:
BFAR
BID
CASP1
CASP14
CASP2
CASP3
CASP4
CASP6
CASP7
CASP8
CASP8AP2
CASP9
CCAR1
CFLAR
DEDD
DEDD2
DSP
ECE2
FADD
NFKBIL1
OIP5
PHF20L1
POLR2A
PRDX6
RB1
RIOK3
RYBP
TNFRSF1A
TRAF1
XIAP
12 interacting genes:
BCL2
CASP10
CASP8
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2K
UBE2N
UBE2U
UBE2W
Entrez ID
843
51283
HPRD ID
03458
16548
Ensembl ID
ENSG00000003400
ENSG00000103429
Uniprot IDs
A0A0S2Z3G5
A0A0S2Z3Z5
Q92851
H3BMP2
Q9NZS9
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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