DCUN1D5 and UBE2M

Data Source:
BioGRID (pull down)

		DCUN1D5	UBE2M
Description		defective in cullin neddylation 1 domain containing 5	ubiquitin conjugating enzyme E2 M
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Spindle	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding NEDD8 Transferase Activity
	Biological Process	Regulation Of Cell Growth Cellular Response To DNA Damage Stimulus Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation	Cellular Protein Modification Process Protein Phosphopantetheinylation Positive Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation
Pathways		Neddylation	TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diisocyanate-induced asthma ( 25918132) Interleukin-10 levels ( 22205395) Toenail selenium levels ( 25343990) Tuberculosis ( 24057671)	Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		11 interacting genes: CAND1 CHUK CUL2 CUL3 HUS1 LNX1 PICK1 PLEKHG4 RCHY1 UBE2F UBE2M	30 interacting genes: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3
Entrez ID		84259	9040
HPRD ID		14520	04414
Ensembl ID		ENSG00000137692	ENSG00000130725
Uniprot IDs		A0A024R3A2 B4DP84 Q9BTE7	A0A024R4T4 P61081
PDB IDs			1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O
Enriched GO Terms of Interacting Partners?
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