DCUN1D5 and CAND1

Data Source:
BioGRID (pull down)

		DCUN1D5	CAND1
Description		defective in cullin neddylation 1 domain containing 5	cullin associated and neddylation dissociated 1
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Spindle	Ubiquitin Ligase Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Cullin-RING Ubiquitin Ligase Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Protein Binding TBP-class Protein Binding
	Biological Process	Regulation Of Cell Growth Cellular Response To DNA Damage Stimulus Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation	Cellular Iron Ion Homeostasis SCF Complex Assembly Protein Ubiquitination Cell Differentiation Negative Regulation Of Catalytic Activity Neutrophil Degranulation Post-translational Protein Modification Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Pathways		Neddylation	Neutrophil degranulation Neddylation Iron uptake and transport
Drugs
Diseases
GWAS		Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diisocyanate-induced asthma ( 25918132) Interleukin-10 levels ( 22205395) Toenail selenium levels ( 25343990) Tuberculosis ( 24057671)	Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Expressive vocabulary in infants ( 25226531) HDL cholesterol levels ( 32203549) Hippocampal atrophy ( 19668339) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549)
Interacting Genes		11 interacting genes: CAND1 CHUK CUL2 CUL3 HUS1 LNX1 PICK1 PLEKHG4 RCHY1 UBE2F UBE2M	18 interacting genes: CA9 CNOT3 CUL1 CUL2 CUL3 CUL4A CUL4B DCUN1D1 DCUN1D2 DCUN1D4 DCUN1D5 DUX4 LNPK MTNR1A RBX1 SKP1 SRPK2 UBE2M
Entrez ID		84259	55832
HPRD ID		14520	06983
Ensembl ID		ENSG00000137692	ENSG00000111530
Uniprot IDs		A0A024R3A2 B4DP84 Q9BTE7	Q86VP6
PDB IDs			1U6G 4A0C
Enriched GO Terms of Interacting Partners?
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