EEA1 and RAB5B

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		EEA1	RAB5B
Description		early endosome antigen 1	RAB5B, member RAS oncogene family
Image
GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Serine-pyruvate Aminotransferase Complex Membrane Extrinsic Component Of Plasma Membrane Early Endosome Membrane Axonal Spine Recycling Endosome Extracellular Exosome	Endosome Early Endosome Plasma Membrane Endomembrane System Membrane Endocytic Vesicle Secretory Granule Membrane Early Endosome Membrane Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity	GTPase Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding
	Biological Process	Endocytosis Vesicle Fusion Synaptic Vesicle To Endosome Fusion Viral RNA Genome Replication Early Endosome To Late Endosome Transport	Intracellular Protein Transport Endocytosis Endosome Organization Antigen Processing And Presentation Regulation Of Endocytosis Neutrophil Degranulation Plasma Membrane To Endosome Transport
Pathways		Toll Like Receptor 9 (TLR9) Cascade	Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		Inositol 1,3-Bisphosphate
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Sensorimotor dexterity ( 31596458) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Western dietary pattern ( 28644415)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Asthma ( 31959851 30929738 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) FEV1 ( 30804560) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30804560) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401) Polycystic ovary syndrome ( 22885925 30566500) Refractive error ( 32231278) Sum eosinophil basophil counts ( 27863252) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)
Interacting Genes		13 interacting genes: IGF1R MAPK14 RAB22A RAB31 RAB5A RAB5B RAB5C RRAD STX12 STX6 TOM1 USO1 ZFYVE16	16 interacting genes: APOA5 CDK1 CHM EEA1 GLP1R PIK3CB RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SUN2 TBC1D15 TBC1D17 TFRC
Entrez ID		8411	5869
HPRD ID		05460	01544
Ensembl ID		ENSG00000102189	ENSG00000111540
Uniprot IDs		Q15075	A0A024RB09 P61020
PDB IDs		1HYI 1HYJ 1JOC 3MJH	2HEI
Enriched GO Terms of Interacting Partners?
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