SLC41A2 and IL27RA

Data Source:
BioGRID (two hybrid)

		SLC41A2	IL27RA
Description		solute carrier family 41 member 2	interleukin 27 receptor subunit alpha
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Protein Binding Inorganic Cation Transmembrane Transporter Activity	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-12 Receptor Binding Protein Binding Cytokine Binding Interleukin-23 Binding Interleukin-27 Receptor Activity
	Biological Process	Metal Ion Transport Cation Transmembrane Transport	Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Activated T Cell Proliferation Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation
Pathways		Metal ion SLC transporters	Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
Drugs
Diseases
GWAS		Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction) ( 33012170)	Blood protein levels ( 30072576 29875488) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		31 interacting genes: AQP6 CD79A CLN5 CREB3 EBP ERGIC3 ERVFRD-1 FATE1 FNDC9 FUT3 GJA5 GJB5 GPR151 GPR42 GPX8 IGFBP5 IL27RA KASH5 KIR3DL3 LDLRAD1 LEUTX LIME1 LMNA LY6G6C LYVE1 MFF PDCD1LG2 PVR SHISAL1 SSMEM1 TMEM237	12 interacting genes: BRICD5 CLDN2 DEFB121 DERL3 EBI3 GALNT15 IL27 MAPK8 MFSD5 SLC41A2 STAT1 YIPF6
Entrez ID		84102	9466
HPRD ID		15389	09247
Ensembl ID		ENSG00000136052	ENSG00000104998
Uniprot IDs		Q96JW4	Q6UWB1
PDB IDs
Enriched GO Terms of Interacting Partners?
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